| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
|---|
| Ligand | BDBM50129325 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_151534 (CHEMBL762247) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Das, J; Lin, J; Moquin, RV; Shen, Z; Spergel, SH; Wityak, J; Doweyko, AM; DeFex, HF; Fang, Q; Pang, S; Pitt, S; Shen, DR; Schieven, GL; Barrish, JC Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117. Bioorg Med Chem Lett13:2145-9 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Lck |
|---|
| Name: | Tyrosine-protein kinase Lck |
|---|
| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 57987.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06239 |
|---|
| Residue: | 509 |
|---|
| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
|
|
|
|---|
| BDBM50129325 |
|---|
| n/a |
|---|
| Name | BDBM50129325 |
|---|
| Synonyms: | 2-[(2-Hydroxymethyl-cyclopropanecarbonyl)-amino]-benzothiazole-6-carboxylic acid (2-chloro-6-methyl-phenyl)-amide | CHEMBL68261 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18ClN3O3S |
|---|
| Mol. Mass. | 415.893 |
|---|
| SMILES | Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3CO)sc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
