Reaction Details |
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Target | Tyrosine-protein kinase JAK3 |
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Ligand | BDBM50132426 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_91950 |
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IC50 | 700±n/a nM |
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Citation | Adams, C; Aldous, DJ; Amendola, S; Bamborough, P; Bright, C; Crowe, S; Eastwood, P; Fenton, G; Foster, M; Harrison, TK; King, S; Lai, J; Lawrence, C; Letallec, JP; McCarthy, C; Moorcroft, N; Page, K; Rao, S; Redford, J; Sadiq, S; Smith, K; Souness, JE; Thurairatnam, S; Vine, M; Wyman, B Mapping the kinase domain of Janus Kinase 3. Bioorg Med Chem Lett13:3105-10 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK3 |
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Name: | Tyrosine-protein kinase JAK3 |
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase |
Type: | Protein |
Mol. Mass.: | 125111.08 |
Organism: | Homo sapiens (Human) |
Description: | P52333 |
Residue: | 1124 |
Sequence: | MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA
SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL
RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR
PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM
DLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP
LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK
EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR
HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ
EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS
GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
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BDBM50132426 |
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n/a |
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Name | BDBM50132426 |
Synonyms: | CHEMBL104062 | N-{4-[2-Oxo-5-(thiophene-2-carbonyl)-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-acetamide |
Type | Small organic molecule |
Emp. Form. | C22H16N2O3S |
Mol. Mass. | 388.439 |
SMILES | CC(=O)Nc1ccc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2cccs2)cc1 |
Structure |
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