Reaction Details |
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Target | L-lactate dehydrogenase A chain |
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Ligand | BDBM489104 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2109290 (CHEMBL4817965) |
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IC50 | 314±n/a nM |
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Citation | Christov, PP; Kim, K; Jana, S; Romaine, IM; Rai, G; Mott, BT; Allweil, AA; Lamers, A; Brimacombe, KR; Urban, DJ; Lee, TD; Hu, X; Lukacs, CM; Davies, DR; Jadhav, A; Hall, MD; Green, N; Moore, WJ; Stott, GM; Flint, AJ; Maloney, DJ; Sulikowski, GA; Waterson, AG Optimization of ether and aniline based inhibitors of lactate dehydrogenase. Bioorg Med Chem Lett41:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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L-lactate dehydrogenase A chain |
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Name: | L-lactate dehydrogenase A chain |
Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
Type: | Protein |
Mol. Mass.: | 36694.85 |
Organism: | Homo sapiens (Human) |
Description: | P00338::PDB Code: 4ajp |
Residue: | 332 |
Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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BDBM489104 |
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n/a |
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Name | BDBM489104 |
Synonyms: | 2-(5- (cyclopropylmethyl)- 3-(3- (phenylamino)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; | US10961200, Compound 485 | US11247971, Cmpd ID 485 |
Type | Small organic molecule |
Emp. Form. | C30H27N5O4S2 |
Mol. Mass. | 585.696 |
SMILES | NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2cccc(Nc3ccccc3)c2)-c2nc(cs2)C(O)=O)cc1 |
Structure |
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