Ki Summary

Reaction Details

Report a problem with these data

Target

Dual specificity protein kinase TTK

Ligand

BDBM50569973

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2110865 (CHEMBL4819715)

3.9±n/a nM

Citation

Huang, M; Huang, Y; Guo, J; Yu, L; Chang, Y; Wang, X; Luo, J; Huang, Y; Tu, Z; Lu, X; Xu, Y; Zhang, Z; Zhang, Z; Ding, K Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors. Eur J Med Chem211:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity protein kinase TTK

Name:

Dual specificity protein kinase TTK

Synonyms:

Type:

Protein

Mol. Mass.:

97086.79

Organism:

Homo sapiens (Human)

Description:

P33981

Residue:

857

Sequence:

MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK

BDBM50569973

n/a

Name

BDBM50569973

Synonyms:

CHEMBL4863607

Type

Small organic molecule

Emp. Form.

C29H39N7O2

Mol. Mass.

517.6657

SMILES

CCC(=O)N[C@H]1CC[C@H](CC1)n1c2nc(Nc3ccc(N4CCN(C)CC4)c(C)c3)ncc2c(C)cc1=O |r,wU:8.11,5.4,(45.43,-27.67,;45.45,-29.21,;44.12,-30,;44.15,-31.54,;42.78,-29.24,;42.76,-27.7,;41.42,-26.95,;41.4,-25.41,;42.72,-24.62,;44.06,-25.38,;44.08,-26.92,;42.7,-23.08,;41.36,-22.33,;40.04,-23.12,;38.69,-22.37,;37.36,-23.15,;36.02,-22.4,;36.01,-20.86,;34.66,-20.11,;33.33,-20.9,;31.99,-20.15,;30.67,-20.93,;29.32,-20.18,;29.3,-18.64,;27.96,-17.89,;30.63,-17.86,;31.97,-18.61,;33.36,-22.44,;32.04,-23.23,;34.7,-23.19,;38.67,-20.83,;39.99,-20.04,;41.33,-20.79,;42.66,-20,;42.64,-18.46,;44.01,-20.76,;44.03,-22.3,;45.37,-23.05,)|

Structure