Ki Summary

Reaction Details

Report a problem with these data

Target

Dual specificity protein kinase TTK

Ligand

BDBM50569985

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2110865 (CHEMBL4819715)

1.5±n/a nM

Citation

Huang, M; Huang, Y; Guo, J; Yu, L; Chang, Y; Wang, X; Luo, J; Huang, Y; Tu, Z; Lu, X; Xu, Y; Zhang, Z; Zhang, Z; Ding, K Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors. Eur J Med Chem211:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity protein kinase TTK

Name:

Dual specificity protein kinase TTK

Synonyms:

Type:

Protein

Mol. Mass.:

97086.79

Organism:

Homo sapiens (Human)

Description:

P33981

Residue:

857

Sequence:

MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK

BDBM50569985

n/a

Name

BDBM50569985

Synonyms:

CHEMBL4874692

Type

Small organic molecule

Emp. Form.

C30H41N7O3

Mol. Mass.

547.6916

SMILES

CCC(=O)N[C@H]1CC[C@H](CC1)n1c2nc(Nc3ccc(cc3OC)N3CCN(C)CC3)ncc2c(CC)cc1=O |r,wU:8.11,5.4,(26.59,-17.84,;26.61,-19.38,;25.28,-20.16,;25.3,-21.7,;23.94,-19.4,;23.93,-17.86,;22.59,-17.11,;22.57,-15.56,;23.9,-14.78,;25.24,-15.54,;25.25,-17.08,;23.88,-13.24,;22.54,-12.48,;21.22,-13.27,;19.87,-12.51,;18.54,-13.29,;17.2,-12.54,;17.19,-11,;15.85,-10.24,;14.52,-11.02,;14.54,-12.56,;15.88,-13.32,;15.89,-14.86,;14.57,-15.64,;13.17,-10.26,;11.85,-11.05,;10.51,-10.29,;10.49,-8.75,;9.15,-8,;11.82,-7.97,;13.16,-8.72,;19.85,-10.97,;21.18,-10.19,;22.53,-10.94,;23.85,-10.16,;23.84,-8.62,;25.16,-7.84,;25.19,-10.92,;25.21,-12.46,;26.55,-13.22,)|

Structure