| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
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| Ligand | BDBM13246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_69442 |
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| IC50 | 71.0±n/a nM |
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| Citation |  Wityak, J; Das, J; Moquin, RV; Shen, Z; Lin, J; Chen, P; Doweyko, AM; Pitt, S; Pang, S; Shen, DR; Fang, Q; de Fex, HF; Schieven, GL; Kanner, SB; Barrish, JC Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett13:4007-10 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fyn |
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| Name: | Tyrosine-protein kinase Fyn |
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| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
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| Type: | Enzyme |
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| Mol. Mass.: | 60762.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06241 |
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| Residue: | 537 |
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| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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| BDBM13246 |
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| n/a |
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| Name | BDBM13246 |
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| Synonyms: | 5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3-thiazole-2,5-diamido | BMS-354825 2-Carboxamido-4-hydrido-thiazole Analog 7n | CHEMBL131577 | N-(2-chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-1,3-thiazole-5-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14ClN3O2S |
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| Mol. Mass. | 335.809 |
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| SMILES | Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1 |
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| Structure | 
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