| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50142060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143775 |
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| IC50 | 12000±n/a nM |
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| Citation |  Beaulieu, PL; Bös, M; Bousquet, Y; DeRoy, P; Fazal, G; Gauthier, J; Gillard, J; Goulet, S; McKercher, G; Poupart, MA; Valois, S; Kukolj, G Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency. Bioorg Med Chem Lett14:967-71 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50142060 |
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| n/a |
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| Name | BDBM50142060 |
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| Synonyms: | 1-Cyclohexyl-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid [1-((S)-3,4-dimethoxy-phenyl)-ethyl]-amide | CHEMBL173638 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N4O3 |
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| Mol. Mass. | 484.5894 |
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| SMILES | COc1ccc(cc1OC)[C@H](C)NC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccccn1 |
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| Structure | 
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