| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Ligand | BDBM50577543 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2130517 (CHEMBL4839946) |
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| EC50 | 1650±n/a nM |
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| Citation |  Zhang, J; Zou, L; Shi, D; Liu, J; Zhang, J; Zhao, R; Wang, G; Zhang, L; Ouyang, L; Liu, B Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer. J Med Chem64:14192-14216 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Synonyms: | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3 |
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| Type: | Protein |
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| Mol. Mass.: | 43582.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NTG7 |
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| Residue: | 399 |
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| Sequence: | MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
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| BDBM50577543 |
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| n/a |
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| Name | BDBM50577543 |
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| Synonyms: | CHEMBL4874517 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31I2NO3 |
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| Mol. Mass. | 671.3489 |
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| SMILES | CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCCN2CCCCC2)c(I)c1 |
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| Structure | 
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