Reaction Details |
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Target | Arginase-1 |
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Ligand | BDBM50579614 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2135941 (CHEMBL4845551) |
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IC50 | 1.6±n/a nM |
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Citation | Li, D; Zhang, H; Lyons, TW; Lu, M; Achab, A; Pu, Q; Childers, M; Mitcheltree, MJ; Wang, J; Martinot, TA; McMinn, SE; Sloman, DL; Palani, A; Beard, A; Nogle, L; Gathiaka, S; Saurí, J; Kim, HY; Adpressa, D; Spacciapoli, P; Miller, JR; Palte, RL; Lesburg, CA; Cumming, J; Fischer, C Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors. ACS Med Chem Lett12:1678-1688 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Arginase-1 |
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Name: | Arginase-1 |
Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
Type: | PROTEIN |
Mol. Mass.: | 34737.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_978893 |
Residue: | 322 |
Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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BDBM50579614 |
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n/a |
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Name | BDBM50579614 |
Synonyms: | CHEMBL4871970 |
Type | Small organic molecule |
Emp. Form. | C10H19BN2O4 |
Mol. Mass. | 242.08 |
SMILES | [H][C@]12CN[C@H](C(O)=O)[C@@]1(CCCB(O)O)CCN2 |r| |
Structure |
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