| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
|---|
| Ligand | BDBM50148680 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_39655 |
|---|
| IC50 | 15000±n/a nM |
|---|
| Citation |  Shankaran, K; Donnelly, KL; Shah, SK; Caldwell, CG; Chen, P; Finke, PE; Oates, B; MacCoss, M; Mills, SG; DeMartino, JA; Gould, SL; Malkowitz, L; Siciliano, SJ; Springer, MS; Kwei, G; Carella, A; Carver, G; Danzeisen, R; Hazuda, D; Holmes, K; Kessler, J; Lineberger, J; Miller, MD; Emini, EA; Schleif, WA Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists. Bioorg Med Chem Lett14:3589-93 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 5 |
|---|
| Name: | C-C chemokine receptor type 5 |
|---|
| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 40540.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51681 |
|---|
| Residue: | 352 |
|---|
| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
|
|
|
|---|
| BDBM50148680 |
|---|
| n/a |
|---|
| Name | BDBM50148680 |
|---|
| Synonyms: | Allyl-[1-(6-oxo-3,6-diphenyl-hexyl)-piperidin-4-yl]-carbamic acid 4-nitro-benzyl ester | CHEMBL118501 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H39N3O5 |
|---|
| Mol. Mass. | 569.6906 |
|---|
| SMILES | [O-][N+](=O)c1ccc(COC(=O)N(CC=C)C2CCN(CCC(CCC(=O)c3ccccc3)c3ccccc3)CC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
