Reaction Details |
| Report a problem with these data |
Target | C-C chemokine receptor type 5 |
---|
Ligand | BDBM50148689 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_39655 |
---|
IC50 | 88000±n/a nM |
---|
Citation | Shankaran, K; Donnelly, KL; Shah, SK; Caldwell, CG; Chen, P; Finke, PE; Oates, B; MacCoss, M; Mills, SG; DeMartino, JA; Gould, SL; Malkowitz, L; Siciliano, SJ; Springer, MS; Kwei, G; Carella, A; Carver, G; Danzeisen, R; Hazuda, D; Holmes, K; Kessler, J; Lineberger, J; Miller, MD; Emini, EA; Schleif, WA Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists. Bioorg Med Chem Lett14:3589-93 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
C-C chemokine receptor type 5 |
---|
Name: | C-C chemokine receptor type 5 |
Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
Type: | Enzyme |
Mol. Mass.: | 40540.21 |
Organism: | Homo sapiens (Human) |
Description: | P51681 |
Residue: | 352 |
Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
|
|
|
BDBM50148689 |
---|
n/a |
---|
Name | BDBM50148689 |
Synonyms: | CHEMBL120513 | [1-(5-Benzenesulfonyl-3-phenyl-heptyl)-piperidin-4-yl]-ethyl-carbamic acid benzyl ester |
Type | Small organic molecule |
Emp. Form. | C34H44N2O4S |
Mol. Mass. | 576.789 |
SMILES | CCC(CC(CCN1CCC(CC1)N(CC)C(=O)OCc1ccccc1)c1ccccc1)S(=O)(=O)c1ccccc1 |
Structure |
|