| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
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| Ligand | BDBM50584465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2160025 (CHEMBL5044775) |
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| EC50 | 20±n/a nM |
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| Citation |  Feng, Z; Xiang, J; Liu, H; Li, J; Xu, X; Sun, G; Zheng, R; Zhang, S; Liu, J; Yang, S; Xu, Q; Wen, X; Yuan, H; Sun, H; Dai, L Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPAR?/? Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem65:2571-2592 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor delta |
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| Name: | Peroxisome proliferator-activated receptor delta |
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| Synonyms: | NUC1 | Nr1c2 | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR-beta | PPAR-delta | PPARD_MOUSE | Pparb | Ppard |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49719.14 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1288931 |
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| Residue: | 440 |
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| Sequence: | MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMG
CDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKN
RNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQHNPQLADLKAFSKH
IYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEI
SVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKD
GLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDR
PGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLK
KTESETLLHPLLQEIYKDMY
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| BDBM50584465 |
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| n/a |
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| Name | BDBM50584465 |
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| Synonyms: | CHEMBL5084377 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22F3N3O5 |
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| Mol. Mass. | 465.4224 |
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| SMILES | Cc1cc(Cn2ncn(-c3ccc(OC(F)(F)F)cc3)c2=O)cc(C)c1OC(C)(C)C(O)=O |
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| Structure | 
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