| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GTPase KRas |
|---|
| Ligand | BDBM50585382 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2162437 (CHEMBL5047298) |
|---|
| Kd | 6200±n/a nM |
|---|
| Citation |  Wang, X; Allen, S; Blake, JF; Bowcut, V; Briere, DM; Calinisan, A; Dahlke, JR; Fell, JB; Fischer, JP; Gunn, RJ; Hallin, J; Laguer, J; Lawson, JD; Medwid, J; Newhouse, B; Nguyen, P; O'Leary, JM; Olson, P; Pajk, S; Rahbaek, L; Rodriguez, M; Smith, CR; Tang, TP; Thomas, NC; Vanderpool, D; Vigers, GP; Christensen, JG; Marx, MA Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS J Med Chem65:3123-3133 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| GTPase KRas |
|---|
| Name: | GTPase KRas |
|---|
| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 21656.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1476955 |
|---|
| Residue: | 189 |
|---|
| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
|
|
|---|
| BDBM50585382 |
|---|
| n/a |
|---|
| Name | BDBM50585382 |
|---|
| Synonyms: | CHEMBL5085395 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H31FN6O2 |
|---|
| Mol. Mass. | 502.5831 |
|---|
| SMILES | CN1CCC[C@H]1COc1nc(N2CCN(C)CC2)c2cnc(c(F)c2n1)-c1cc(O)cc2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
