| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-8 |
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| Ligand | BDBM50587109 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2170917 (CHEMBL5056051) |
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| IC50 | 69±n/a nM |
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| Citation |  Zhang, H; Hsu, HC; Kahne, SC; Hara, R; Zhan, W; Jiang, X; Burns-Huang, K; Ouellette, T; Imaeda, T; Okamoto, R; Kawasaki, M; Michino, M; Wong, TT; Toita, A; Yukawa, T; Moraca, F; Vendome, J; Saha, P; Sato, K; Aso, K; Ginn, J; Meinke, PT; Foley, M; Nathan, CF; Darwin, KH; Li, H; Lin, G Macrocyclic Peptides that Selectively Inhibit the J Med Chem64:6262-6272 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-8 |
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| Name: | Proteasome subunit beta type-8 |
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| Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30357.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446797 |
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| Residue: | 276 |
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| Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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| BDBM50587109 |
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| n/a |
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| Name | BDBM50587109 |
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| Synonyms: | CHEMBL5079787 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H41FN4O5 |
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| Mol. Mass. | 592.7008 |
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| SMILES | Fc1ccccc1CNC(=O)[C@@H]1CCCCOc2cccc(CCC(=O)N[C@@H](CC(=O)N3CCC[C@@H]3C3CC3)C(=O)N1)c2 |r| |
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| Structure | 
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