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TargetCalpain-1 catalytic subunit
LigandBDBM50167708
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304655 (CHEMBL827857)
IC50 450±n/a nM
Citation Lee, KSSeo, SHLee, YHKim, HDSon, MHChung, BYLee, JYJin, CLee, YS Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors. Bioorg Med Chem Lett15:2857-60 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calpain-1 catalytic subunit
Name:Calpain-1 catalytic subunit
Synonyms:CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:Protein
Mol. Mass.:81880.51
Organism:Homo sapiens (Human)
Description:n/a
Residue:714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50167708
n/a
NameBDBM50167708
Synonyms:3-Ethyl-4-oxo-4H-chromene-2-carboxylic acid ((S)-1-benzyl-2-carbamoyl-2-oxo-ethyl)-amide | CHEMBL196671
TypeSmall organic molecule
Emp. Form.C22H20N2O5
Mol. Mass.392.4046
SMILESCCc1c(oc2ccccc2c1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(N)=O
Structure
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