| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein |
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| Ligand | BDBM50599441 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2230518 (CHEMBL5144290) |
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| IC50 | 530±n/a nM |
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| Citation |  Liu, Z; Gu, S; Zhu, X; Liu, M; Cao, Z; Qiu, P; Li, S; Liu, S; Song, G Discovery and optimization of new 6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline derivatives as potent influenza virus PA Eur J Med Chem227:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein |
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| Name: | Polymerase acidic protein |
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| Synonyms: | Hepatitis C virus polyprotein | PA | PA/PB1 | PA_I34A1 | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82573.84 |
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| Organism: | Hepatitis C virus |
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| Description: | ChEMBL_64976 |
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| Residue: | 716 |
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| Sequence: | MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQ
EMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNG
YIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNM
KKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
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| BDBM50599441 |
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| n/a |
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| Name | BDBM50599441 |
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| Synonyms: | CHEMBL5182912 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21NO7 |
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| Mol. Mass. | 387.3832 |
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| SMILES | COC(=O)[C@@H]1Cc2cc(O)c(O)cc2[C@H](Cc2ccc(O)c(O)c2)N1C(C)=O |r| |
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| Structure | 
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