| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
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| Ligand | BDBM176258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2234808 (CHEMBL5148580) |
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| IC50 | 0.600000±n/a nM |
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| Citation |  Priestley, ES; Banville, J; Deon, D; Dubé, L; Gagnon, M; Guy, J; Lapointe, P; Lavallée, JF; Martel, A; Plamondon, S; Rémillard, R; Ruediger, E; Tremblay, F; Posy, SL; Guarino, VR; Richter, JM; Li, J; Gupta, A; Vetrichelvan, M; Balapragalathan, TJ; Mathur, A; Hua, J; Callejo, M; Guay, J; Sum, CS; Cvijic, ME; Watson, C; Wong, P; Yang, J; Bouvier, M; Gordon, DA; Wexler, RR; Marinier, A Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4. J Med Chem65:8843-8854 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 4 |
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| Name: | Proteinase-activated receptor 4 |
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| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
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| Type: | Protein |
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| Mol. Mass.: | 41145.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI0 |
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| Residue: | 385 |
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| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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| BDBM176258 |
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| n/a |
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| Name | BDBM176258 |
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| Synonyms: | US10047103, 291 | US9688695, 291 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H23F2N5O5S2 |
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| Mol. Mass. | 623.65 |
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| SMILES | COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N3CCC(F)(F)C3)cc(OC)cc2o1 |
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| Structure | 
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