| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor VII/Tissue factor |
|---|
| Ligand | BDBM50189939 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_393411 (CHEMBL913194) |
|---|
| Ki | 1.3±n/a nM |
|---|
| Citation |  Hu, H; Kolesnikov, A; Riggs, JR; Wesson, KE; Stephens, R; Leahy, EM; Shrader, WD; Sprengeler, PA; Green, MJ; Sanford, E; Nguyen, M; Gjerstad, E; Cabuslay, R; Young, WB Potent 4-amino-5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett16:4567-70 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor VII/Tissue factor |
|---|
| Name: | Coagulation factor VII/Tissue factor |
|---|
| Synonyms: | Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 69535 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Tissue factor |
|---|
| Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 33067.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_936735 |
|---|
| Residue: | 295 |
|---|
| Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
|
|
|
|---|
| Component 2 |
| Name: | Coagulation factor VII |
|---|
| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51599.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
|
|
|
|---|
| BDBM50189939 |
|---|
| n/a |
|---|
| Name | BDBM50189939 |
|---|
| Synonyms: | 5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-6-hydroxy-3'-[((S)-2-hydroxy-3-phenyl-propionylamino)-methyl]-biphenyl-3-carboxylic acid | CHEMBL386638 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H26N4O5 |
|---|
| Mol. Mass. | 522.5512 |
|---|
| SMILES | Nc1nccc2[nH]c(cc12)-c1cc(cc(-c2cccc(CNC(=O)[C@@H](O)Cc3ccccc3)c2)c1O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
