| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit alpha |
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| Ligand | BDBM50199310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_420145 (CHEMBL912715) |
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| IC50 | 5.3±n/a nM |
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| Citation |  Enkvist, E; Lavogina, D; Raidaru, G; Vaasa, A; Viil, I; Lust, M; Viht, K; Uri, A Conjugation of adenosine and hexa-(D-arginine) leads to a nanomolar bisubstrate-analog inhibitor of basophilic protein kinases. J Med Chem49:7150-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit alpha |
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| Name: | cAMP-dependent protein kinase catalytic subunit alpha |
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| Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit |
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| Type: | Enzyme Catalytic Subunit |
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| Mol. Mass.: | 40598.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 351 |
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| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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| BDBM50199310 |
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| n/a |
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| Name | BDBM50199310 |
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| Synonyms: | 2S,3S,4R,5R)-5-6-amino-9H-purin-9-yl)-N-12R,15R,18R,21R,24R,27R)-12,15,18,21,24,27-hexakis3-guanidinopropyl)-1-isoquinoline-5-sulfonamido)-9,11,14,17,20,23,26,29-octaoxo-3,10,13,16,19,22,25,28-o ctaazatetratriacontan-34-yl)-3,4-dihydroxytetrahydrofuran-2-carboxamide | CHEMBL413460 |
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| Type | Small organic molecule |
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| Emp. Form. | C69H116N34O14S |
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| Mol. Mass. | 1677.944 |
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| SMILES | NC(=N)NCCC[C@@H](NC(=O)CCCCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)NC(=O)CCCCCNCCNS(=O)(=O)c1cccc2cnccc12 |
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| Structure | 
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