Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase 21 |
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Ligand | BDBM50612976 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2290625 |
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IC50 | >25000±n/a nM |
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Citation | Göricke, F; Vu, V; Smith, L; Scheib, U; Böhm, R; Akkilic, N; Wohlfahrt, G; Weiske, J; Bömer, U; Brzezinka, K; Lindner, N; Lienau, P; Gradl, S; Beck, H; Brown, PJ; Santhakumar, V; Vedadi, M; Barsyte-Lovejoy, D; Arrowsmith, CH; Schmees, N; Petersen, K Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. J Med Chem66:3431-3447 (2023) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase 21 |
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Name: | Ubiquitin carboxyl-terminal hydrolase 21 |
Synonyms: | Deubiquitinating enzyme 21 | UBP21_HUMAN | USP21 | USP23 | Ubiquitin thioesterase 21 | Ubiquitin-specific-processing protease 21 |
Type: | PROTEIN |
Mol. Mass.: | 62692.84 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105198 |
Residue: | 565 |
Sequence: | MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
SENQVASSEGYVLFYQLMQEPPRCL
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BDBM50612976 |
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n/a |
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Name | BDBM50612976 |
Synonyms: | CHEMBL5266959 |
Type | Small organic molecule |
Emp. Form. | C17H21N5O5S |
Mol. Mass. | 407.444 |
SMILES | COCC(NC(=O)C(C)C)C(=O)Nc1nnc(Cc2ccc(cc2)[N+]([O-])=O)s1 |
Structure |
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