| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 21 |
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| Ligand | BDBM50612988 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2290626 |
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| IC50 | 11±n/a nM |
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| Citation |  Göricke, F; Vu, V; Smith, L; Scheib, U; Böhm, R; Akkilic, N; Wohlfahrt, G; Weiske, J; Bömer, U; Brzezinka, K; Lindner, N; Lienau, P; Gradl, S; Beck, H; Brown, PJ; Santhakumar, V; Vedadi, M; Barsyte-Lovejoy, D; Arrowsmith, CH; Schmees, N; Petersen, K Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. J Med Chem66:3431-3447 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 21 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 21 |
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| Synonyms: | Deubiquitinating enzyme 21 | UBP21_HUMAN | USP21 | USP23 | Ubiquitin thioesterase 21 | Ubiquitin-specific-processing protease 21 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62692.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105198 |
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| Residue: | 565 |
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| Sequence: | MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
SENQVASSEGYVLFYQLMQEPPRCL
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| BDBM50612988 |
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| n/a |
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| Name | BDBM50612988 |
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| Synonyms: | CHEMBL5286335 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F3N5O3S |
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| Mol. Mass. | 481.491 |
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| SMILES | OC[C@@H](NC(=O)C1(CCCCC1)C(F)(F)F)C(=O)Nc1nnc(Cc2ccc(cc2)C#N)s1 |r| |
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| Structure | 
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