| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
|---|
| Ligand | BDBM50199602 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_453433 (CHEMBL885432) |
|---|
| Ki | 13±n/a nM |
|---|
| Citation |  Letavic, MA; Keith, JM; Jablonowski, JA; Stocking, EM; Gomez, LA; Ly, KS; Miller, JM; Barbier, AJ; Bonaventure, P; Boggs, JD; Wilson, SJ; Miller, KL; Lord, B; McAllister, HM; Tognarelli, DJ; Wu, J; Abad, MC; Schubert, C; Lovenberg, TW; Carruthers, NI Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors. Bioorg Med Chem Lett17:1047-51 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent serotonin transporter |
|---|
| Name: | Sodium-dependent serotonin transporter |
|---|
| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 70322.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31645 |
|---|
| Residue: | 630 |
|---|
| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
|
|
|---|
| BDBM50199602 |
|---|
| n/a |
|---|
| Name | BDBM50199602 |
|---|
| Synonyms: | (S)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methylmorpholino)propoxy)-1,2,3,4-tetrahydroisoquinoline | CHEMBL395609 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H34N2O3 |
|---|
| Mol. Mass. | 410.5491 |
|---|
| SMILES | COc1ccc(cc1)[C@@H]1CN(C)Cc2cc(OCCCN3CCOC[C@@H]3C)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
