Ki Summary

Reaction Details

Report a problem with these data

Target

Insulin-like growth factor 1 receptor

Ligand

BDBM50199661

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_453490 (CHEMBL885484)

IC50

81±n/a nM

Citation

Mulvihill, MJ; Ji, QS; Werner, D; Beck, P; Cesario, C; Cooke, A; Cox, M; Crew, A; Dong, H; Feng, L; Foreman, KW; Mak, G; Nigro, A; O'Connor, M; Saroglou, L; Stolz, KM; Sujka, I; Volk, B; Weng, Q; Wilkes, R 1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors. Bioorg Med Chem Lett17:1091-7 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Insulin-like growth factor 1 receptor

Name:

Insulin-like growth factor 1 receptor

Synonyms:

Type:

Protein

Mol. Mass.:

154776.79

Organism:

Homo sapiens (Human)

Description:

P08069

Residue:

1367

Sequence:

MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH
NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR
KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV
VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
EIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC

BDBM50199661

n/a

Name

BDBM50199661

Synonyms:

CHEMBL240035 | trans-3-(-4-(azetidin-1-ylmethyl)cyclohexyl)-1-(3-(benzyloxy)phenyl)imidazo[1,5-a]pyrazin-8-amine

Type

Small organic molecule

Emp. Form.

C29H33N5O

Mol. Mass.

467.6052

SMILES

Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCC2)CC1 |wU:27.31,wD:24.27,(7.51,1.57,;7.52,.03,;6.19,-.74,;6.19,-2.29,;7.52,-3.06,;8.86,-2.29,;10.33,-2.77,;11.25,-1.51,;10.33,-.26,;10.81,1.21,;9.77,2.34,;10.24,3.8,;11.76,4.13,;12.79,2.99,;14.29,3.31,;15.32,2.16,;16.83,2.48,;17.85,1.34,;19.36,1.66,;19.83,3.12,;18.8,4.27,;17.29,3.94,;12.31,1.52,;8.86,-.74,;10.81,-4.23,;9.78,-5.38,;10.25,-6.84,;11.75,-7.17,;12.23,-8.63,;13.73,-8.96,;14.56,-10.26,;15.85,-9.42,;15.02,-8.13,;12.79,-6.02,;12.32,-4.55,)|

Structure