Found 111 hits with Last Name = 'foreman' and Initial = 'kw' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199659
(CHEMBL392788 | US8481733, Comparator 1 | cis-3-(3-...)Show SMILES NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:4.6,2.1,(-3.93,-46.02,;-5.43,-45.7,;-5.91,-44.24,;-7.28,-43.54,;-6.58,-42.18,;-5.21,-42.87,;-7.06,-40.71,;-6.15,-39.45,;-7.06,-38.2,;-6.59,-36.73,;-7.62,-35.6,;-7.15,-34.14,;-5.64,-33.81,;-4.61,-34.96,;-3.1,-34.64,;-2.07,-35.78,;-.56,-35.46,;.46,-36.61,;1.96,-36.29,;2.44,-34.82,;1.4,-33.67,;-.1,-34,;-5.08,-36.42,;-8.54,-38.68,;-9.88,-37.92,;-9.88,-36.38,;-11.2,-38.69,;-11.2,-40.23,;-9.87,-41,;-8.54,-40.23,)| Show InChI InChI=1S/C24H25N5O/c25-14-17-11-19(12-17)24-28-21(22-23(26)27-9-10-29(22)24)18-7-4-8-20(13-18)30-15-16-5-2-1-3-6-16/h1-10,13,17,19H,11-12,14-15,25H2,(H2,26,27)/t17-,19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199661
(CHEMBL240035 | trans-3-(-4-(azetidin-1-ylmethyl)cy...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCC2)CC1 |wU:27.31,wD:24.27,(7.51,1.57,;7.52,.03,;6.19,-.74,;6.19,-2.29,;7.52,-3.06,;8.86,-2.29,;10.33,-2.77,;11.25,-1.51,;10.33,-.26,;10.81,1.21,;9.77,2.34,;10.24,3.8,;11.76,4.13,;12.79,2.99,;14.29,3.31,;15.32,2.16,;16.83,2.48,;17.85,1.34,;19.36,1.66,;19.83,3.12,;18.8,4.27,;17.29,3.94,;12.31,1.52,;8.86,-.74,;10.81,-4.23,;9.78,-5.38,;10.25,-6.84,;11.75,-7.17,;12.23,-8.63,;13.73,-8.96,;14.56,-10.26,;15.85,-9.42,;15.02,-8.13,;12.79,-6.02,;12.32,-4.55,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(24-8-4-9-25(18-24)35-20-22-6-2-1-3-7-22)32-29(34(27)17-14-31-28)23-12-10-21(11-13-23)19-33-15-5-16-33/h1-4,6-9,14,17-18,21,23H,5,10-13,15-16,19-20H2,(H2,30,31)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199632
(CHEMBL239985 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,26.30,(25.65,-17.79,;25.65,-19.33,;24.33,-20.1,;24.33,-21.64,;25.66,-22.41,;27,-21.64,;28.47,-22.12,;29.38,-20.86,;28.47,-19.61,;28.95,-18.14,;27.91,-17.01,;28.38,-15.55,;29.89,-15.22,;30.93,-16.37,;32.43,-16.05,;33.46,-17.19,;34.97,-16.87,;35.99,-18.02,;37.5,-17.7,;37.97,-16.23,;36.93,-15.08,;35.43,-15.41,;30.45,-17.83,;26.99,-20.09,;28.95,-23.59,;28.25,-24.95,;29.62,-25.65,;30.1,-27.11,;31.6,-27.43,;32.23,-28.84,;33.77,-28.68,;34.09,-27.17,;32.75,-26.4,;30.32,-24.28,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199624
(CHEMBL392082 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCOCC2)CC1 |wU:27.31,wD:24.27,(-9.11,-17.4,;-9.11,-18.94,;-10.43,-19.71,;-10.45,-21.25,;-9.1,-22.03,;-7.77,-21.26,;-6.29,-21.74,;-5.38,-20.48,;-6.29,-19.22,;-5.82,-17.76,;-6.85,-16.63,;-6.38,-15.16,;-4.87,-14.84,;-3.84,-15.98,;-2.33,-15.66,;-1.3,-16.81,;.21,-16.49,;1.23,-17.63,;2.73,-17.31,;3.21,-15.84,;2.17,-14.7,;.67,-15.02,;-4.31,-17.45,;-7.77,-19.7,;-5.81,-23.2,;-6.85,-24.35,;-6.37,-25.81,;-4.87,-26.13,;-4.4,-27.6,;-2.89,-27.92,;-2.43,-29.39,;-.93,-29.71,;.11,-28.58,;-.36,-27.11,;-1.86,-26.77,;-3.84,-24.99,;-4.31,-23.52,)| Show InChI InChI=1S/C30H35N5O2/c31-29-28-27(25-7-4-8-26(19-25)37-21-23-5-2-1-3-6-23)33-30(35(28)14-13-32-29)24-11-9-22(10-12-24)20-34-15-17-36-18-16-34/h1-8,13-14,19,22,24H,9-12,15-18,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199623
(CHEMBL394155 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCCC2)CC1 |wU:27.31,wD:24.27,(25.91,1,;25.92,-.54,;24.59,-1.31,;24.59,-2.85,;25.92,-3.62,;27.26,-2.85,;28.74,-3.33,;29.65,-2.08,;28.74,-.82,;29.21,.64,;28.18,1.78,;28.65,3.24,;30.16,3.57,;31.19,2.42,;32.7,2.74,;33.73,1.6,;35.23,1.92,;36.26,.77,;37.76,1.09,;38.24,2.56,;37.2,3.7,;35.7,3.38,;30.71,.96,;27.26,-1.3,;29.21,-4.8,;28.18,-5.94,;28.65,-7.4,;30.16,-7.73,;30.63,-9.2,;32.13,-9.52,;32.76,-10.92,;34.29,-10.76,;34.62,-9.26,;33.29,-8.48,;31.19,-6.59,;30.72,-5.12,)| Show InChI InChI=1S/C30H35N5O/c31-29-28-27(25-9-6-10-26(19-25)36-21-23-7-2-1-3-8-23)33-30(35(28)18-15-32-29)24-13-11-22(12-14-24)20-34-16-4-5-17-34/h1-3,6-10,15,18-19,22,24H,4-5,11-14,16-17,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199668
(CHEMBL240034 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES CCN(CC)C[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.5,wD:9.12,(.11,-7.88,;-1.4,-7.56,;-2.43,-8.7,;-1.96,-10.17,;-.45,-10.49,;-3.94,-8.38,;-4.41,-6.91,;-5.91,-6.58,;-6.38,-5.12,;-5.35,-3.98,;-3.84,-4.29,;-3.37,-5.77,;-5.83,-2.51,;-4.92,-1.25,;-5.83,0,;-5.35,1.47,;-6.39,2.6,;-5.92,4.06,;-4.41,4.39,;-3.37,3.24,;-1.87,3.56,;-.84,2.42,;.67,2.74,;1.69,1.59,;3.2,1.91,;3.67,3.38,;2.63,4.53,;1.13,4.2,;-3.85,1.78,;-7.3,-.48,;-8.65,.28,;-8.65,1.82,;-9.97,-.49,;-9.97,-2.03,;-8.64,-2.8,;-7.3,-2.03,)| Show InChI InChI=1S/C30H37N5O/c1-3-34(4-2)20-22-13-15-24(16-14-22)30-33-27(28-29(31)32-17-18-35(28)30)25-11-8-12-26(19-25)36-21-23-9-6-5-7-10-23/h5-12,17-19,22,24H,3-4,13-16,20-21H2,1-2H3,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199666
(CHEMBL437558 | trans-1-(3-(benzyloxy)phenyl)-3-(3-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,wD:26.30,(8.59,-17.92,;8.59,-19.46,;7.27,-20.23,;7.27,-21.77,;8.6,-22.54,;9.94,-21.77,;11.41,-22.25,;12.32,-20.99,;11.41,-19.74,;11.89,-18.27,;10.85,-17.14,;11.32,-15.68,;12.83,-15.35,;13.87,-16.5,;15.37,-16.18,;16.4,-17.32,;17.91,-17,;18.93,-18.14,;20.44,-17.83,;20.91,-16.36,;19.87,-15.21,;18.37,-15.54,;13.39,-17.96,;9.94,-20.22,;11.89,-23.71,;13.26,-24.41,;12.56,-25.78,;13.04,-27.24,;14.55,-27.56,;15.17,-28.97,;16.71,-28.81,;17.03,-27.3,;15.69,-26.53,;11.19,-25.08,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199640
(CHEMBL392284 | trans3-(-4-(aminomethyl)cyclohexyl)...)Show SMILES NC[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:2.1,wD:5.8,(13.4,-48.47,;11.89,-48.15,;11.42,-46.68,;9.92,-46.36,;9.44,-44.9,;10.48,-43.75,;11.98,-44.07,;12.45,-45.54,;10,-42.29,;10.91,-41.03,;10,-39.77,;10.47,-38.31,;9.44,-37.18,;9.91,-35.71,;11.42,-35.39,;12.45,-36.53,;13.96,-36.21,;14.99,-37.36,;16.5,-37.04,;17.52,-38.18,;19.02,-37.86,;19.5,-36.39,;18.46,-35.25,;16.96,-35.57,;11.98,-38,;8.52,-40.25,;7.18,-39.49,;7.18,-37.95,;5.86,-40.26,;5.86,-41.81,;7.19,-42.58,;8.52,-41.81,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199686
(CHEMBL393314 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(m...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCOCC2)C1 |wU:24.27,26.30,(-9.93,2.7,;-9.92,1.16,;-11.25,.39,;-11.25,-1.15,;-9.92,-1.92,;-8.58,-1.15,;-7.1,-1.63,;-6.19,-.37,;-7.1,.88,;-6.63,2.35,;-7.66,3.48,;-7.19,4.94,;-5.68,5.27,;-4.65,4.12,;-3.14,4.44,;-2.11,3.3,;-.61,3.62,;.42,2.48,;1.92,2.79,;2.4,4.26,;1.36,5.41,;-.14,5.08,;-5.12,2.66,;-8.58,.4,;-6.63,-3.09,;-7.33,-4.46,;-5.95,-5.16,;-5.48,-6.62,;-3.97,-6.94,;-3.51,-8.41,;-2.01,-8.73,;-.97,-7.59,;-1.44,-6.12,;-2.95,-5.8,;-5.26,-3.79,)| Show InChI InChI=1S/C28H31N5O2/c29-27-26-25(22-7-4-8-24(17-22)35-19-20-5-2-1-3-6-20)31-28(33(26)10-9-30-27)23-15-21(16-23)18-32-11-13-34-14-12-32/h1-10,17,21,23H,11-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199626
(CHEMBL401429 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CN(C)C[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.8,4.3,(13.74,-47.62,;13.26,-46.15,;14.29,-45.01,;11.76,-45.84,;11.28,-44.37,;9.91,-43.67,;10.61,-42.31,;11.98,-43,;10.13,-40.84,;11.04,-39.59,;10.13,-38.33,;10.6,-36.87,;9.57,-35.73,;10.04,-34.27,;11.55,-33.94,;12.58,-35.09,;14.09,-34.77,;15.12,-35.91,;16.63,-35.59,;17.65,-36.74,;19.15,-36.42,;19.63,-34.95,;18.59,-33.8,;17.09,-34.13,;12.11,-36.55,;8.65,-38.81,;7.31,-38.05,;7.3,-36.51,;5.99,-38.82,;5.98,-40.36,;7.31,-41.13,;8.65,-40.36,)| Show InChI InChI=1S/C26H29N5O/c1-30(2)16-19-13-21(14-19)26-29-23(24-25(27)28-11-12-31(24)26)20-9-6-10-22(15-20)32-17-18-7-4-3-5-8-18/h3-12,15,19,21H,13-14,16-17H2,1-2H3,(H2,27,28)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199626
(CHEMBL401429 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CN(C)C[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.8,4.3,(13.74,-47.62,;13.26,-46.15,;14.29,-45.01,;11.76,-45.84,;11.28,-44.37,;9.91,-43.67,;10.61,-42.31,;11.98,-43,;10.13,-40.84,;11.04,-39.59,;10.13,-38.33,;10.6,-36.87,;9.57,-35.73,;10.04,-34.27,;11.55,-33.94,;12.58,-35.09,;14.09,-34.77,;15.12,-35.91,;16.63,-35.59,;17.65,-36.74,;19.15,-36.42,;19.63,-34.95,;18.59,-33.8,;17.09,-34.13,;12.11,-36.55,;8.65,-38.81,;7.31,-38.05,;7.3,-36.51,;5.99,-38.82,;5.98,-40.36,;7.31,-41.13,;8.65,-40.36,)| Show InChI InChI=1S/C26H29N5O/c1-30(2)16-19-13-21(14-19)26-29-23(24-25(27)28-11-12-31(24)26)20-9-6-10-22(15-20)32-17-18-7-4-3-5-8-18/h3-12,15,19,21H,13-14,16-17H2,1-2H3,(H2,27,28)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 191 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199641
(1-(3-(2,6-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4c(F)cccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-18-8-3-9-19(25)17(18)13-30-16-7-2-6-15(12-16)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 215 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199650
(CHEMBL240613 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CC(C)NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:7.9,5.4,(15.38,-7.53,;13.87,-7.21,;13.4,-5.74,;12.84,-8.35,;11.34,-8.03,;10.86,-6.57,;9.49,-5.87,;10.19,-4.51,;11.56,-5.2,;9.71,-3.04,;10.62,-1.79,;9.71,-.53,;10.18,.93,;9.15,2.07,;9.62,3.53,;11.13,3.86,;12.16,2.71,;13.67,3.03,;14.7,1.89,;16.21,2.21,;17.23,1.06,;18.73,1.38,;19.21,2.85,;18.17,4,;16.67,3.67,;11.69,1.25,;8.23,-1.01,;6.89,-.25,;6.88,1.29,;5.57,-1.02,;5.56,-2.56,;6.9,-3.33,;8.23,-2.56,)| Show InChI InChI=1S/C27H31N5O/c1-18(2)30-16-20-13-22(14-20)27-31-24(25-26(28)29-11-12-32(25)27)21-9-6-10-23(15-21)33-17-19-7-4-3-5-8-19/h3-12,15,18,20,22,30H,13-14,16-17H2,1-2H3,(H2,28,29)/t20-,22+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199630
(1-(3-(2-fluorobenzyloxy)phenyl)-3-cyclobutylimidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H21FN4O/c24-19-10-2-1-5-17(19)14-29-18-9-4-8-16(13-18)20-21-22(25)26-11-12-28(21)23(27-20)15-6-3-7-15/h1-2,4-5,8-13,15H,3,6-7,14H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199631
(CHEMBL394154 | cis-3-(4-(aminomethyl)cyclohexyl)-1...)Show SMILES NC[C@H]1CC[C@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:5.8,2.1,(30.07,-50.41,;28.57,-50.08,;28.1,-48.62,;26.59,-48.29,;26.12,-46.83,;27.15,-45.68,;28.66,-46,;29.13,-47.47,;26.68,-44.22,;27.59,-42.96,;26.67,-41.71,;27.15,-40.24,;26.12,-39.11,;26.58,-37.65,;28.1,-37.32,;29.13,-38.47,;30.63,-38.15,;31.66,-39.29,;33.17,-38.97,;34.19,-40.11,;35.7,-39.79,;36.18,-38.33,;35.14,-37.18,;33.63,-37.51,;28.65,-39.93,;25.2,-42.19,;23.86,-41.43,;23.85,-39.89,;22.53,-42.2,;22.53,-43.74,;23.86,-44.51,;25.2,-43.74,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199638
(CHEMBL393313 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCCC2)C1 |wU:24.27,26.30,(24.76,-37.15,;24.77,-38.69,;23.45,-39.46,;23.44,-41,;24.78,-41.77,;26.11,-41,;27.59,-41.48,;28.5,-40.22,;27.59,-38.97,;28.06,-37.5,;27.03,-36.37,;27.5,-34.91,;29.01,-34.58,;30.04,-35.73,;31.55,-35.41,;32.58,-36.55,;34.09,-36.23,;35.11,-37.38,;36.61,-37.06,;37.09,-35.59,;36.05,-34.44,;34.55,-34.77,;29.57,-37.19,;26.11,-39.45,;28.07,-42.94,;27.37,-44.31,;28.74,-45.01,;29.22,-46.47,;30.72,-46.79,;31.19,-48.26,;32.69,-48.58,;33.72,-47.44,;33.25,-45.97,;31.74,-45.65,;29.44,-43.64,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(23-10-7-11-25(18-23)35-20-21-8-3-1-4-9-21)32-29(34(27)15-12-31-28)24-16-22(17-24)19-33-13-5-2-6-14-33/h1,3-4,7-12,15,18,22,24H,2,5-6,13-14,16-17,19-20H2,(H2,30,31)/t22-,24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 237 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199676
(1-(3-(2-chloro-6-fluorobenzyloxy)phenyl)-3-cyclobu...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4c(F)cccc4Cl)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20ClFN4O/c24-18-8-3-9-19(25)17(18)13-30-16-7-2-6-15(12-16)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 248 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199665
(1-(3-(2,5-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cc(F)ccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-17-7-8-19(25)16(11-17)13-30-18-6-2-5-15(12-18)20-21-22(26)27-9-10-29(21)23(28-20)14-3-1-4-14/h2,5-12,14H,1,3-4,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 329 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199665
(1-(3-(2,5-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cc(F)ccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-17-7-8-19(25)16(11-17)13-30-18-6-2-5-15(12-18)20-21-22(26)27-9-10-29(21)23(28-20)14-3-1-4-14/h2,5-12,14H,1,3-4,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 329 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199689
(1-(3-(2-chlorobenzyloxy)phenyl)-3-cyclobutylimidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4Cl)c3)c12)C1CCC1 Show InChI InChI=1S/C23H21ClN4O/c24-19-10-2-1-5-17(19)14-29-18-9-4-8-16(13-18)20-21-22(25)26-11-12-28(21)23(27-20)15-6-3-7-15/h1-2,4-5,8-13,15H,3,6-7,14H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 343 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199638
(CHEMBL393313 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCCC2)C1 |wU:24.27,26.30,(24.76,-37.15,;24.77,-38.69,;23.45,-39.46,;23.44,-41,;24.78,-41.77,;26.11,-41,;27.59,-41.48,;28.5,-40.22,;27.59,-38.97,;28.06,-37.5,;27.03,-36.37,;27.5,-34.91,;29.01,-34.58,;30.04,-35.73,;31.55,-35.41,;32.58,-36.55,;34.09,-36.23,;35.11,-37.38,;36.61,-37.06,;37.09,-35.59,;36.05,-34.44,;34.55,-34.77,;29.57,-37.19,;26.11,-39.45,;28.07,-42.94,;27.37,-44.31,;28.74,-45.01,;29.22,-46.47,;30.72,-46.79,;31.19,-48.26,;32.69,-48.58,;33.72,-47.44,;33.25,-45.97,;31.74,-45.65,;29.44,-43.64,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(23-10-7-11-25(18-23)35-20-21-8-3-1-4-9-21)32-29(34(27)15-12-31-28)24-16-22(17-24)19-33-13-5-2-6-14-33/h1,3-4,7-12,15,18,22,24H,2,5-6,13-14,16-17,19-20H2,(H2,30,31)/t22-,24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 346 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199650
(CHEMBL240613 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CC(C)NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:7.9,5.4,(15.38,-7.53,;13.87,-7.21,;13.4,-5.74,;12.84,-8.35,;11.34,-8.03,;10.86,-6.57,;9.49,-5.87,;10.19,-4.51,;11.56,-5.2,;9.71,-3.04,;10.62,-1.79,;9.71,-.53,;10.18,.93,;9.15,2.07,;9.62,3.53,;11.13,3.86,;12.16,2.71,;13.67,3.03,;14.7,1.89,;16.21,2.21,;17.23,1.06,;18.73,1.38,;19.21,2.85,;18.17,4,;16.67,3.67,;11.69,1.25,;8.23,-1.01,;6.89,-.25,;6.88,1.29,;5.57,-1.02,;5.56,-2.56,;6.9,-3.33,;8.23,-2.56,)| Show InChI InChI=1S/C27H31N5O/c1-18(2)30-16-20-13-22(14-20)27-31-24(25-26(28)29-11-12-32(25)27)21-9-6-10-23(15-21)33-17-19-7-4-3-5-8-19/h3-12,15,18,20,22,30H,13-14,16-17H2,1-2H3,(H2,28,29)/t20-,22+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 376 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199661
(CHEMBL240035 | trans-3-(-4-(azetidin-1-ylmethyl)cy...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCC2)CC1 |wU:27.31,wD:24.27,(7.51,1.57,;7.52,.03,;6.19,-.74,;6.19,-2.29,;7.52,-3.06,;8.86,-2.29,;10.33,-2.77,;11.25,-1.51,;10.33,-.26,;10.81,1.21,;9.77,2.34,;10.24,3.8,;11.76,4.13,;12.79,2.99,;14.29,3.31,;15.32,2.16,;16.83,2.48,;17.85,1.34,;19.36,1.66,;19.83,3.12,;18.8,4.27,;17.29,3.94,;12.31,1.52,;8.86,-.74,;10.81,-4.23,;9.78,-5.38,;10.25,-6.84,;11.75,-7.17,;12.23,-8.63,;13.73,-8.96,;14.56,-10.26,;15.85,-9.42,;15.02,-8.13,;12.79,-6.02,;12.32,-4.55,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(24-8-4-9-25(18-24)35-20-22-6-2-1-3-7-22)32-29(34(27)17-14-31-28)23-12-10-21(11-13-23)19-33-15-5-16-33/h1-4,6-9,14,17-18,21,23H,5,10-13,15-16,19-20H2,(H2,30,31)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199632
(CHEMBL239985 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,26.30,(25.65,-17.79,;25.65,-19.33,;24.33,-20.1,;24.33,-21.64,;25.66,-22.41,;27,-21.64,;28.47,-22.12,;29.38,-20.86,;28.47,-19.61,;28.95,-18.14,;27.91,-17.01,;28.38,-15.55,;29.89,-15.22,;30.93,-16.37,;32.43,-16.05,;33.46,-17.19,;34.97,-16.87,;35.99,-18.02,;37.5,-17.7,;37.97,-16.23,;36.93,-15.08,;35.43,-15.41,;30.45,-17.83,;26.99,-20.09,;28.95,-23.59,;28.25,-24.95,;29.62,-25.65,;30.1,-27.11,;31.6,-27.43,;32.23,-28.84,;33.77,-28.68,;34.09,-27.17,;32.75,-26.4,;30.32,-24.28,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 401 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199668
(CHEMBL240034 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES CCN(CC)C[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.5,wD:9.12,(.11,-7.88,;-1.4,-7.56,;-2.43,-8.7,;-1.96,-10.17,;-.45,-10.49,;-3.94,-8.38,;-4.41,-6.91,;-5.91,-6.58,;-6.38,-5.12,;-5.35,-3.98,;-3.84,-4.29,;-3.37,-5.77,;-5.83,-2.51,;-4.92,-1.25,;-5.83,0,;-5.35,1.47,;-6.39,2.6,;-5.92,4.06,;-4.41,4.39,;-3.37,3.24,;-1.87,3.56,;-.84,2.42,;.67,2.74,;1.69,1.59,;3.2,1.91,;3.67,3.38,;2.63,4.53,;1.13,4.2,;-3.85,1.78,;-7.3,-.48,;-8.65,.28,;-8.65,1.82,;-9.97,-.49,;-9.97,-2.03,;-8.64,-2.8,;-7.3,-2.03,)| Show InChI InChI=1S/C30H37N5O/c1-3-34(4-2)20-22-13-15-24(16-14-22)30-33-27(28-29(31)32-17-18-35(28)30)25-11-8-12-26(19-25)36-21-23-9-6-5-7-10-23/h5-12,17-19,22,24H,3-4,13-16,20-21H2,1-2H3,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Mus musculus) | BDBM50511189
(CHEMBL4571556)Show SMILES CONC(=O)c1cc(ccc1O)C(=O)N1CCC(CC1)c1cccc(CN)c1 Show InChI InChI=1S/C21H25N3O4/c1-28-23-20(26)18-12-17(5-6-19(18)25)21(27)24-9-7-15(8-10-24)16-4-2-3-14(11-16)13-22/h2-6,11-12,15,25H,7-10,13,22H2,1H3,(H,23,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 455 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medicine
Curated by ChEMBL
| Assay Description
Inhibition of mouse MCP6 pre-incubated for 3 hrs before N-tert-butoxycarbonyl-Gln-Ala-Arg-AMC substrate addition and measured every 30 secs for 15 mi... |
J Med Chem 63: 3004-3027 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01689
BindingDB Entry DOI: 10.7270/Q2N3018J |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199625
(1-(3-(3-fluorobenzyloxy)phenyl)-3-cyclobutylimidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cccc(F)c4)c3)c12)C1CCC1 Show InChI InChI=1S/C23H21FN4O/c24-18-8-1-4-15(12-18)14-29-19-9-3-7-17(13-19)20-21-22(25)26-10-11-28(21)23(27-20)16-5-2-6-16/h1,3-4,7-13,16H,2,5-6,14H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199683
(3-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)...)Show InChI InChI=1S/C16H16N4O/c17-15-14-13(11-5-2-6-12(21)9-11)19-16(10-3-1-4-10)20(14)8-7-18-15/h2,5-10,21H,1,3-4H2,(H2,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 518 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199629
(CHEMBL393517 | trans-3-(8-amino-1-(3-(benzyloxy)ph...)Show SMILES NC(=O)[C@H]1C[C@@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:5.7,wD:3.2,(-3.43,-24.86,;-4.94,-24.54,;-5.97,-25.68,;-5.41,-23.07,;-4.72,-21.7,;-6.09,-21.01,;-6.79,-22.38,;-6.56,-19.55,;-5.65,-18.29,;-6.56,-17.03,;-6.09,-15.57,;-7.12,-14.44,;-6.66,-12.97,;-5.14,-12.65,;-4.11,-13.79,;-2.6,-13.47,;-1.57,-14.62,;-.07,-14.3,;.96,-15.44,;2.46,-15.12,;2.94,-13.66,;1.9,-12.51,;.4,-12.83,;-4.59,-15.26,;-8.04,-17.52,;-9.38,-16.75,;-9.39,-15.21,;-10.71,-17.52,;-10.71,-19.07,;-9.38,-19.84,;-8.04,-19.07,)| Show InChI InChI=1S/C24H23N5O2/c25-22-21-20(16-7-4-8-19(13-16)31-14-15-5-2-1-3-6-15)28-24(29(21)10-9-27-22)18-11-17(12-18)23(26)30/h1-10,13,17-18H,11-12,14H2,(H2,25,27)(H2,26,30)/t17-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 526 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199640
(CHEMBL392284 | trans3-(-4-(aminomethyl)cyclohexyl)...)Show SMILES NC[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:2.1,wD:5.8,(13.4,-48.47,;11.89,-48.15,;11.42,-46.68,;9.92,-46.36,;9.44,-44.9,;10.48,-43.75,;11.98,-44.07,;12.45,-45.54,;10,-42.29,;10.91,-41.03,;10,-39.77,;10.47,-38.31,;9.44,-37.18,;9.91,-35.71,;11.42,-35.39,;12.45,-36.53,;13.96,-36.21,;14.99,-37.36,;16.5,-37.04,;17.52,-38.18,;19.02,-37.86,;19.5,-36.39,;18.46,-35.25,;16.96,-35.57,;11.98,-38,;8.52,-40.25,;7.18,-39.49,;7.18,-37.95,;5.86,-40.26,;5.86,-41.81,;7.19,-42.58,;8.52,-41.81,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 534 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199623
(CHEMBL394155 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCCC2)CC1 |wU:27.31,wD:24.27,(25.91,1,;25.92,-.54,;24.59,-1.31,;24.59,-2.85,;25.92,-3.62,;27.26,-2.85,;28.74,-3.33,;29.65,-2.08,;28.74,-.82,;29.21,.64,;28.18,1.78,;28.65,3.24,;30.16,3.57,;31.19,2.42,;32.7,2.74,;33.73,1.6,;35.23,1.92,;36.26,.77,;37.76,1.09,;38.24,2.56,;37.2,3.7,;35.7,3.38,;30.71,.96,;27.26,-1.3,;29.21,-4.8,;28.18,-5.94,;28.65,-7.4,;30.16,-7.73,;30.63,-9.2,;32.13,-9.52,;32.76,-10.92,;34.29,-10.76,;34.62,-9.26,;33.29,-8.48,;31.19,-6.59,;30.72,-5.12,)| Show InChI InChI=1S/C30H35N5O/c31-29-28-27(25-9-6-10-26(19-25)36-21-23-7-2-1-3-8-23)33-30(35(28)18-15-32-29)24-13-11-22(12-14-24)20-34-16-4-5-17-34/h1-3,6-10,15,18-19,22,24H,4-5,11-14,16-17,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 547 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199631
(CHEMBL394154 | cis-3-(4-(aminomethyl)cyclohexyl)-1...)Show SMILES NC[C@H]1CC[C@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:5.8,2.1,(30.07,-50.41,;28.57,-50.08,;28.1,-48.62,;26.59,-48.29,;26.12,-46.83,;27.15,-45.68,;28.66,-46,;29.13,-47.47,;26.68,-44.22,;27.59,-42.96,;26.67,-41.71,;27.15,-40.24,;26.12,-39.11,;26.58,-37.65,;28.1,-37.32,;29.13,-38.47,;30.63,-38.15,;31.66,-39.29,;33.17,-38.97,;34.19,-40.11,;35.7,-39.79,;36.18,-38.33,;35.14,-37.18,;33.63,-37.51,;28.65,-39.93,;25.2,-42.19,;23.86,-41.43,;23.85,-39.89,;22.53,-42.2,;22.53,-43.74,;23.86,-44.51,;25.2,-43.74,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Mus musculus) | BDBM50511187
(CHEMBL4542067)Show SMILES NCc1ccc2OCC3(CCN(CC3)C(=O)c3ccc(Cl)c(c3)-c3cccc(c3)B(O)O)c2c1 Show InChI InChI=1S/C26H26BClN2O4/c28-23-6-5-19(14-21(23)18-2-1-3-20(13-18)27(32)33)25(31)30-10-8-26(9-11-30)16-34-24-7-4-17(15-29)12-22(24)26/h1-7,12-14,32-33H,8-11,15-16,29H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 599 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medicine
Curated by ChEMBL
| Assay Description
Inhibition of mouse MCP6 pre-incubated for 3 hrs before N-tert-butoxycarbonyl-Gln-Ala-Arg-AMC substrate addition and measured every 30 secs for 15 mi... |
J Med Chem 63: 3004-3027 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01689
BindingDB Entry DOI: 10.7270/Q2N3018J |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM1779
(CHEMBL392106 | US8481733, Comparator 2)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)C1CCC1 Show InChI InChI=1S/C23H22N4O/c24-22-21-20(26-23(17-8-4-9-17)27(21)13-12-25-22)18-10-5-11-19(14-18)28-15-16-6-2-1-3-7-16/h1-3,5-7,10-14,17H,4,8-9,15H2,(H2,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 606 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199666
(CHEMBL437558 | trans-1-(3-(benzyloxy)phenyl)-3-(3-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,wD:26.30,(8.59,-17.92,;8.59,-19.46,;7.27,-20.23,;7.27,-21.77,;8.6,-22.54,;9.94,-21.77,;11.41,-22.25,;12.32,-20.99,;11.41,-19.74,;11.89,-18.27,;10.85,-17.14,;11.32,-15.68,;12.83,-15.35,;13.87,-16.5,;15.37,-16.18,;16.4,-17.32,;17.91,-17,;18.93,-18.14,;20.44,-17.83,;20.91,-16.36,;19.87,-15.21,;18.37,-15.54,;13.39,-17.96,;9.94,-20.22,;11.89,-23.71,;13.26,-24.41,;12.56,-25.78,;13.04,-27.24,;14.55,-27.56,;15.17,-28.97,;16.71,-28.81,;17.03,-27.3,;15.69,-26.53,;11.19,-25.08,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 621 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199624
(CHEMBL392082 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCOCC2)CC1 |wU:27.31,wD:24.27,(-9.11,-17.4,;-9.11,-18.94,;-10.43,-19.71,;-10.45,-21.25,;-9.1,-22.03,;-7.77,-21.26,;-6.29,-21.74,;-5.38,-20.48,;-6.29,-19.22,;-5.82,-17.76,;-6.85,-16.63,;-6.38,-15.16,;-4.87,-14.84,;-3.84,-15.98,;-2.33,-15.66,;-1.3,-16.81,;.21,-16.49,;1.23,-17.63,;2.73,-17.31,;3.21,-15.84,;2.17,-14.7,;.67,-15.02,;-4.31,-17.45,;-7.77,-19.7,;-5.81,-23.2,;-6.85,-24.35,;-6.37,-25.81,;-4.87,-26.13,;-4.4,-27.6,;-2.89,-27.92,;-2.43,-29.39,;-.93,-29.71,;.11,-28.58,;-.36,-27.11,;-1.86,-26.77,;-3.84,-24.99,;-4.31,-23.52,)| Show InChI InChI=1S/C30H35N5O2/c31-29-28-27(25-7-4-8-26(19-25)37-21-23-5-2-1-3-6-23)33-30(35(28)14-13-32-29)24-11-9-22(10-12-24)20-34-15-17-36-18-16-34/h1-8,13-14,19,22,24H,9-12,15-18,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 651 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199686
(CHEMBL393314 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(m...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCOCC2)C1 |wU:24.27,26.30,(-9.93,2.7,;-9.92,1.16,;-11.25,.39,;-11.25,-1.15,;-9.92,-1.92,;-8.58,-1.15,;-7.1,-1.63,;-6.19,-.37,;-7.1,.88,;-6.63,2.35,;-7.66,3.48,;-7.19,4.94,;-5.68,5.27,;-4.65,4.12,;-3.14,4.44,;-2.11,3.3,;-.61,3.62,;.42,2.48,;1.92,2.79,;2.4,4.26,;1.36,5.41,;-.14,5.08,;-5.12,2.66,;-8.58,.4,;-6.63,-3.09,;-7.33,-4.46,;-5.95,-5.16,;-5.48,-6.62,;-3.97,-6.94,;-3.51,-8.41,;-2.01,-8.73,;-.97,-7.59,;-1.44,-6.12,;-2.95,-5.8,;-5.26,-3.79,)| Show InChI InChI=1S/C28H31N5O2/c29-27-26-25(22-7-4-8-24(17-22)35-19-20-5-2-1-3-6-20)31-28(33(26)10-9-30-27)23-15-21(16-23)18-32-11-13-34-14-12-32/h1-10,17,21,23H,11-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 658 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199659
(CHEMBL392788 | US8481733, Comparator 1 | cis-3-(3-...)Show SMILES NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:4.6,2.1,(-3.93,-46.02,;-5.43,-45.7,;-5.91,-44.24,;-7.28,-43.54,;-6.58,-42.18,;-5.21,-42.87,;-7.06,-40.71,;-6.15,-39.45,;-7.06,-38.2,;-6.59,-36.73,;-7.62,-35.6,;-7.15,-34.14,;-5.64,-33.81,;-4.61,-34.96,;-3.1,-34.64,;-2.07,-35.78,;-.56,-35.46,;.46,-36.61,;1.96,-36.29,;2.44,-34.82,;1.4,-33.67,;-.1,-34,;-5.08,-36.42,;-8.54,-38.68,;-9.88,-37.92,;-9.88,-36.38,;-11.2,-38.69,;-11.2,-40.23,;-9.87,-41,;-8.54,-40.23,)| Show InChI InChI=1S/C24H25N5O/c25-14-17-11-19(12-17)24-28-21(22-23(26)27-9-10-29(22)24)18-7-4-8-20(13-18)30-15-16-5-2-1-3-6-16/h1-10,13,17,19H,11-12,14-15,25H2,(H2,26,27)/t17-,19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199675
(CHEMBL239360 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CN(C[C@H]1C[C@H](C1)C1=NC(C2N1C=CN=C2N)c1cccc(OCc2ccccc2)c1)N1CCNCC1 |wU:5.7,3.2,c:14,16,t:8,(28.09,-10.51,;27.61,-9.05,;26.1,-8.73,;25.63,-7.26,;24.25,-6.56,;24.95,-5.2,;26.33,-5.89,;24.48,-3.73,;25.39,-2.48,;24.48,-1.22,;23,-1.7,;23,-3.26,;21.66,-4.03,;20.33,-3.26,;20.33,-1.71,;21.66,-.94,;21.65,.6,;24.95,.24,;23.92,1.37,;24.39,2.84,;25.9,3.16,;26.93,2.02,;28.44,2.34,;29.47,1.2,;30.97,1.52,;32,.37,;33.5,.69,;33.98,2.16,;32.94,3.3,;31.44,2.98,;26.46,.56,;28.64,-7.9,;30.14,-8.23,;31.17,-7.09,;30.7,-5.62,;29.19,-5.3,;28.16,-6.44,)| Show InChI InChI=1S/C29H37N7O/c1-34(35-13-10-31-11-14-35)19-22-16-24(17-22)29-33-26(27-28(30)32-12-15-36(27)29)23-8-5-9-25(18-23)37-20-21-6-3-2-4-7-21/h2-9,12,15,18,22,24,26-27,31H,10-11,13-14,16-17,19-20H2,1H3,(H2,30,32)/t22-,24+,26?,27? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 758 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199675
(CHEMBL239360 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CN(C[C@H]1C[C@H](C1)C1=NC(C2N1C=CN=C2N)c1cccc(OCc2ccccc2)c1)N1CCNCC1 |wU:5.7,3.2,c:14,16,t:8,(28.09,-10.51,;27.61,-9.05,;26.1,-8.73,;25.63,-7.26,;24.25,-6.56,;24.95,-5.2,;26.33,-5.89,;24.48,-3.73,;25.39,-2.48,;24.48,-1.22,;23,-1.7,;23,-3.26,;21.66,-4.03,;20.33,-3.26,;20.33,-1.71,;21.66,-.94,;21.65,.6,;24.95,.24,;23.92,1.37,;24.39,2.84,;25.9,3.16,;26.93,2.02,;28.44,2.34,;29.47,1.2,;30.97,1.52,;32,.37,;33.5,.69,;33.98,2.16,;32.94,3.3,;31.44,2.98,;26.46,.56,;28.64,-7.9,;30.14,-8.23,;31.17,-7.09,;30.7,-5.62,;29.19,-5.3,;28.16,-6.44,)| Show InChI InChI=1S/C29H37N7O/c1-34(35-13-10-31-11-14-35)19-22-16-24(17-22)29-33-26(27-28(30)32-12-15-36(27)29)23-8-5-9-25(18-23)37-20-21-6-3-2-4-7-21/h2-9,12,15,18,22,24,26-27,31H,10-11,13-14,16-17,19-20H2,1H3,(H2,30,32)/t22-,24+,26?,27? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 758 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199656
(1-(3-(2,3-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cccc(F)c4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-18-9-3-7-16(19(18)25)13-30-17-8-2-6-15(12-17)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 898 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199667
(CHEMBL394135 | trans-4-(8-amino-1-(3-(benzyloxy)ph...)Show SMILES NC(=O)[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:3.2,wD:6.9,(-2.55,-7.2,;-4.06,-6.88,;-5.09,-8.02,;-4.53,-5.41,;-6.03,-5.09,;-6.5,-3.63,;-5.47,-2.48,;-3.96,-2.8,;-3.49,-4.27,;-5.95,-1.01,;-5.03,.24,;-5.95,1.5,;-5.47,2.96,;-6.51,4.09,;-6.04,5.56,;-4.53,5.88,;-3.49,4.74,;-1.99,5.06,;-.96,3.92,;.55,4.24,;1.57,3.09,;3.08,3.41,;3.55,4.88,;2.51,6.02,;1.01,5.7,;-3.97,3.28,;-7.42,1.02,;-8.76,1.78,;-8.77,3.32,;-10.09,1.01,;-10.09,-.54,;-8.76,-1.31,;-7.42,-.54,)| Show InChI InChI=1S/C26H27N5O2/c27-24-23-22(20-7-4-8-21(15-20)33-16-17-5-2-1-3-6-17)30-26(31(23)14-13-29-24)19-11-9-18(10-12-19)25(28)32/h1-8,13-15,18-19H,9-12,16H2,(H2,27,29)(H2,28,32)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 898 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199656
(1-(3-(2,3-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cccc(F)c4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-18-9-3-7-16(19(18)25)13-30-17-8-2-6-15(12-17)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 898 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199667
(CHEMBL394135 | trans-4-(8-amino-1-(3-(benzyloxy)ph...)Show SMILES NC(=O)[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:3.2,wD:6.9,(-2.55,-7.2,;-4.06,-6.88,;-5.09,-8.02,;-4.53,-5.41,;-6.03,-5.09,;-6.5,-3.63,;-5.47,-2.48,;-3.96,-2.8,;-3.49,-4.27,;-5.95,-1.01,;-5.03,.24,;-5.95,1.5,;-5.47,2.96,;-6.51,4.09,;-6.04,5.56,;-4.53,5.88,;-3.49,4.74,;-1.99,5.06,;-.96,3.92,;.55,4.24,;1.57,3.09,;3.08,3.41,;3.55,4.88,;2.51,6.02,;1.01,5.7,;-3.97,3.28,;-7.42,1.02,;-8.76,1.78,;-8.77,3.32,;-10.09,1.01,;-10.09,-.54,;-8.76,-1.31,;-7.42,-.54,)| Show InChI InChI=1S/C26H27N5O2/c27-24-23-22(20-7-4-8-21(15-20)33-16-17-5-2-1-3-6-17)30-26(31(23)14-13-29-24)19-11-9-18(10-12-19)25(28)32/h1-8,13-15,18-19H,9-12,16H2,(H2,27,29)(H2,28,32)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 898 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199643
(1-(3-(4-chlorobenzyloxy)phenyl)-3-cyclobutylimidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccc(Cl)cc4)c3)c12)C1CCC1 Show InChI InChI=1S/C23H21ClN4O/c24-18-9-7-15(8-10-18)14-29-19-6-2-5-17(13-19)20-21-22(25)26-11-12-28(21)23(27-20)16-3-1-4-16/h2,5-13,16H,1,3-4,14H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199642
(3-cyclobutyl-1-(3-(cyclohexyloxy)phenyl)imidazo[1,...)Show SMILES Nc1nccn2c(nc(-c3cccc(OC4CCCCC4)c3)c12)C1CCC1 Show InChI InChI=1S/C22H26N4O/c23-21-20-19(25-22(15-6-4-7-15)26(20)13-12-24-21)16-8-5-11-18(14-16)27-17-9-2-1-3-10-17/h5,8,11-15,17H,1-4,6-7,9-10H2,(H2,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199688
(1-(3-(benzyloxy)phenyl)-3-cyclopentylimidazo[1,5-a...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)C1CCCC1 Show InChI InChI=1S/C24H24N4O/c25-23-22-21(27-24(18-9-4-5-10-18)28(22)14-13-26-23)19-11-6-12-20(15-19)29-16-17-7-2-1-3-8-17/h1-3,6-8,11-15,18H,4-5,9-10,16H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199682
(3-cyclobutyl-1-(3-(pyridin-2-ylmethoxy)phenyl)imid...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccn4)c3)c12)C1CCC1 Show InChI InChI=1S/C22H21N5O/c23-21-20-19(26-22(15-5-3-6-15)27(20)12-11-25-21)16-7-4-9-18(13-16)28-14-17-8-1-2-10-24-17/h1-2,4,7-13,15H,3,5-6,14H2,(H2,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199654
(3-cyclobutyl-1-(3-(cyclohexylmethoxy)phenyl)imidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCC4CCCCC4)c3)c12)C1CCC1 Show InChI InChI=1S/C23H28N4O/c24-22-21-20(26-23(17-8-4-9-17)27(21)13-12-25-22)18-10-5-11-19(14-18)28-15-16-6-2-1-3-7-16/h5,10-14,16-17H,1-4,6-9,15H2,(H2,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Mus musculus) | BDBM50511190
(CHEMBL4592202)Show SMILES NCc1ccc2OCC3(CCN(CC3)C(=O)c3cccc(c3)-c3cccc(c3)B(O)O)c2c1 Show InChI InChI=1S/C26H27BN2O4/c28-16-18-7-8-24-23(13-18)26(17-33-24)9-11-29(12-10-26)25(30)21-5-1-3-19(14-21)20-4-2-6-22(15-20)27(31)32/h1-8,13-15,31-32H,9-12,16-17,28H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Cornell Medicine
Curated by ChEMBL
| Assay Description
Inhibition of mouse MCP6 pre-incubated for 3 hrs before N-tert-butoxycarbonyl-Gln-Ala-Arg-AMC substrate addition and measured every 30 secs for 15 mi... |
J Med Chem 63: 3004-3027 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01689
BindingDB Entry DOI: 10.7270/Q2N3018J |
More data for this
Ligand-Target Pair | |
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