Reaction Details | |||
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Target | Insulin-like growth factor 1 receptor | ||
Ligand | BDBM50199626 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_453491 (CHEMBL885485) | ||
IC50 | 191±n/a nM | ||
Citation | Mulvihill, MJ; Ji, QS; Werner, D; Beck, P; Cesario, C; Cooke, A; Cox, M; Crew, A; Dong, H; Feng, L; Foreman, KW; Mak, G; Nigro, A; O'Connor, M; Saroglou, L; Stolz, KM; Sujka, I; Volk, B; Weng, Q; Wilkes, R 1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors. Bioorg Med Chem Lett17:1091-7 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin-like growth factor 1 receptor | |||
Name: | Insulin-like growth factor 1 receptor | ||
Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
Type: | Protein | ||
Mol. Mass.: | 154776.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08069 | ||
Residue: | 1367 | ||
Sequence: |
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BDBM50199626 | |||
n/a | |||
Name | BDBM50199626 | ||
Synonyms: | CHEMBL401429 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((dimethylamino)methyl)cyclobutyl)imidazo[1,5-a]pyrazin-8-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C26H29N5O | ||
Mol. Mass. | 427.5414 | ||
SMILES | CN(C)C[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.8,4.3,(13.74,-47.62,;13.26,-46.15,;14.29,-45.01,;11.76,-45.84,;11.28,-44.37,;9.91,-43.67,;10.61,-42.31,;11.98,-43,;10.13,-40.84,;11.04,-39.59,;10.13,-38.33,;10.6,-36.87,;9.57,-35.73,;10.04,-34.27,;11.55,-33.94,;12.58,-35.09,;14.09,-34.77,;15.12,-35.91,;16.63,-35.59,;17.65,-36.74,;19.15,-36.42,;19.63,-34.95,;18.59,-33.8,;17.09,-34.13,;12.11,-36.55,;8.65,-38.81,;7.31,-38.05,;7.3,-36.51,;5.99,-38.82,;5.98,-40.36,;7.31,-41.13,;8.65,-40.36,)| | ||
Structure |