Found 152 hits with Last Name = 'ji' and Initial = 'qs' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375331
(CHEMBL261253)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@H]1C[C@H](CN2CCOCC2)C1 |wU:26.30,wD:28.33,(5.75,-42.52,;5.75,-44.06,;4.43,-44.83,;4.43,-46.37,;5.76,-47.14,;7.1,-46.37,;8.57,-46.85,;9.48,-45.59,;8.57,-44.34,;9.35,-43.01,;8.58,-41.68,;9.35,-40.35,;10.9,-40.36,;11.66,-39.02,;13.21,-39.04,;13.99,-40.37,;13.21,-41.71,;11.67,-41.7,;10.89,-43.02,;15.53,-40.38,;16.3,-41.71,;17.84,-41.71,;18.61,-40.38,;17.83,-39.04,;16.3,-39.05,;7.09,-44.82,;9.05,-48.31,;10.43,-49.01,;9.73,-50.38,;10.21,-51.85,;9.44,-53.18,;7.91,-53.17,;7.13,-54.5,;7.9,-55.83,;9.44,-55.84,;10.2,-54.51,;8.36,-49.68,)| Show InChI InChI=1S/C30H30N6O/c31-29-28-27(23-7-6-22-8-9-25(33-26(22)18-23)21-4-2-1-3-5-21)34-30(36(28)11-10-32-29)24-16-20(17-24)19-35-12-14-37-15-13-35/h1-11,18,20,24H,12-17,19H2,(H2,31,32)/t20-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375334
(CHEMBL411074)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@H](CN2CCOCC2)C1 |wU:26.30,28.33,(-9.18,-42.53,;-9.17,-44.07,;-10.49,-44.84,;-10.5,-46.39,;-9.16,-47.16,;-7.83,-46.39,;-6.35,-46.87,;-5.44,-45.61,;-6.35,-44.35,;-5.57,-43.03,;-6.34,-41.7,;-5.57,-40.37,;-4.02,-40.37,;-3.26,-39.04,;-1.71,-39.05,;-.93,-40.39,;-1.71,-41.72,;-3.25,-41.72,;-4.03,-43.04,;.61,-40.39,;1.38,-41.73,;2.92,-41.73,;3.69,-40.4,;2.91,-39.06,;1.37,-39.06,;-7.83,-44.83,;-5.87,-48.33,;-6.57,-49.7,;-5.19,-50.4,;-4.72,-51.86,;-5.5,-53.2,;-7.02,-53.19,;-7.8,-54.52,;-7.03,-55.85,;-5.49,-55.86,;-4.73,-54.53,;-4.49,-49.03,)| Show InChI InChI=1S/C30H30N6O/c31-29-28-27(23-7-6-22-8-9-25(33-26(22)18-23)21-4-2-1-3-5-21)34-30(36(28)11-10-32-29)24-16-20(17-24)19-35-12-14-37-15-13-35/h1-11,18,20,24H,12-17,19H2,(H2,31,32)/t20-,24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375339
(CHEMBL258648)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@@H](C1)N1CCOCC1 |wU:26.30,28.35,(6.69,-13.61,;6.7,-15.15,;5.37,-15.92,;5.37,-17.47,;6.7,-18.24,;8.04,-17.47,;9.51,-17.95,;10.43,-16.69,;9.51,-15.44,;10.29,-14.11,;9.53,-12.78,;10.29,-11.45,;11.84,-11.45,;12.61,-10.12,;14.15,-10.13,;14.93,-11.47,;14.15,-12.8,;12.61,-12.8,;11.83,-14.12,;16.47,-11.47,;17.24,-12.81,;18.78,-12.81,;19.55,-11.48,;18.77,-10.14,;17.24,-10.14,;8.04,-15.92,;9.99,-19.41,;9.3,-20.78,;10.67,-21.48,;11.37,-20.11,;11.14,-22.94,;10.25,-24.19,;10.88,-25.58,;12.41,-25.73,;13.3,-24.48,;12.67,-23.08,)| Show InChI InChI=1S/C29H28N6O/c30-28-27-26(21-7-6-20-8-9-24(32-25(20)18-21)19-4-2-1-3-5-19)33-29(35(27)11-10-31-28)22-16-23(17-22)34-12-14-36-15-13-34/h1-11,18,22-23H,12-17H2,(H2,30,31)/t22-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375337
(CHEMBL413828)Show SMILES CN(C)C[C@H]1C[C@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |wU:6.8,4.3,(25.03,-21.69,;24.56,-20.23,;23.05,-19.91,;25.59,-19.08,;25.11,-17.62,;23.74,-16.92,;24.43,-15.55,;25.81,-16.24,;23.95,-14.09,;24.86,-12.83,;23.95,-11.57,;24.73,-10.25,;23.97,-8.92,;24.73,-7.59,;26.28,-7.59,;27.05,-6.26,;28.59,-6.27,;29.37,-7.61,;28.59,-8.94,;27.05,-8.94,;26.27,-10.26,;30.91,-7.61,;31.68,-8.95,;33.22,-8.95,;33.99,-7.62,;33.21,-6.28,;31.68,-6.29,;22.48,-12.05,;21.14,-11.29,;21.13,-9.75,;19.81,-12.06,;19.81,-13.61,;21.14,-14.38,;22.48,-13.61,)| Show InChI InChI=1S/C28H28N6/c1-33(2)17-18-14-22(15-18)28-32-25(26-27(29)30-12-13-34(26)28)21-9-8-20-10-11-23(31-24(20)16-21)19-6-4-3-5-7-19/h3-13,16,18,22H,14-15,17H2,1-2H3,(H2,29,30)/t18-,22+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@H](CN2CCC2)C1 |wU:26.30,28.33,(7.04,-25.52,;7.05,-27.06,;5.72,-27.83,;5.72,-29.37,;7.05,-30.15,;8.39,-29.37,;9.86,-29.85,;10.77,-28.6,;9.86,-27.34,;10.64,-26.02,;9.88,-24.69,;10.64,-23.36,;12.19,-23.36,;12.96,-22.02,;14.5,-22.04,;15.28,-23.37,;14.5,-24.71,;12.96,-24.7,;12.18,-26.03,;16.82,-23.38,;17.59,-24.72,;19.13,-24.72,;19.9,-23.38,;19.12,-22.05,;17.59,-22.05,;8.39,-27.82,;10.34,-31.32,;9.65,-32.69,;11.02,-33.38,;11.5,-34.85,;10.47,-35.99,;8.93,-36.07,;9.01,-37.61,;10.55,-37.53,;11.72,-32.01,)| Show InChI InChI=1S/C29H28N6/c30-28-27-26(22-8-7-21-9-10-24(32-25(21)17-22)20-5-2-1-3-6-20)33-29(35(27)14-11-31-28)23-15-19(16-23)18-34-12-4-13-34/h1-3,5-11,14,17,19,23H,4,12-13,15-16,18H2,(H2,30,31)/t19-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375336
(CHEMBL411062)Show SMILES CN(C)C[C@H]1C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |wU:6.8,wD:4.3,(-5.34,-34.06,;-5.81,-32.6,;-7.32,-32.28,;-4.78,-31.45,;-5.26,-29.99,;-4.56,-28.62,;-5.94,-27.92,;-6.63,-29.29,;-6.42,-26.46,;-5.51,-25.2,;-6.42,-23.95,;-5.64,-22.62,;-6.41,-21.29,;-5.64,-19.96,;-4.09,-19.96,;-3.33,-18.63,;-1.78,-18.64,;-1,-19.98,;-1.78,-21.31,;-3.32,-21.31,;-4.1,-22.63,;.54,-19.98,;1.31,-21.32,;2.85,-21.32,;3.62,-19.99,;2.84,-18.65,;1.3,-18.66,;-7.89,-24.43,;-9.24,-23.66,;-9.24,-22.12,;-10.56,-24.43,;-10.56,-25.98,;-9.23,-26.75,;-7.89,-25.98,)| Show InChI InChI=1S/C28H28N6/c1-33(2)17-18-14-22(15-18)28-32-25(26-27(29)30-12-13-34(26)28)21-9-8-20-10-11-23(31-24(20)16-21)19-6-4-3-5-7-19/h3-13,16,18,22H,14-15,17H2,1-2H3,(H2,29,30)/t18-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@H](CN2CCC2)C1 |wU:26.30,28.33,(7.04,-25.52,;7.05,-27.06,;5.72,-27.83,;5.72,-29.37,;7.05,-30.15,;8.39,-29.37,;9.86,-29.85,;10.77,-28.6,;9.86,-27.34,;10.64,-26.02,;9.88,-24.69,;10.64,-23.36,;12.19,-23.36,;12.96,-22.02,;14.5,-22.04,;15.28,-23.37,;14.5,-24.71,;12.96,-24.7,;12.18,-26.03,;16.82,-23.38,;17.59,-24.72,;19.13,-24.72,;19.9,-23.38,;19.12,-22.05,;17.59,-22.05,;8.39,-27.82,;10.34,-31.32,;9.65,-32.69,;11.02,-33.38,;11.5,-34.85,;10.47,-35.99,;8.93,-36.07,;9.01,-37.61,;10.55,-37.53,;11.72,-32.01,)| Show InChI InChI=1S/C29H28N6/c30-28-27-26(22-8-7-21-9-10-24(32-25(21)17-22)20-5-2-1-3-6-20)33-29(35(27)14-11-31-28)23-15-19(16-23)18-34-12-4-13-34/h1-3,5-11,14,17,19,23H,4,12-13,15-16,18H2,(H2,30,31)/t19-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375335
(CHEMBL260298)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@H]1C[C@H](CN2CCC2)C1 |wU:26.30,wD:28.33,(20.91,-25.07,;20.92,-26.61,;19.6,-27.38,;19.59,-28.92,;20.93,-29.69,;22.26,-28.92,;23.74,-29.4,;24.65,-28.14,;23.74,-26.89,;24.51,-25.56,;23.75,-24.23,;24.52,-22.9,;26.07,-22.91,;26.83,-21.57,;28.38,-21.59,;29.16,-22.92,;28.38,-24.26,;26.83,-24.25,;26.06,-25.57,;30.7,-22.93,;31.47,-24.26,;33,-24.27,;33.78,-22.93,;33,-21.59,;31.46,-21.6,;22.26,-27.37,;24.22,-30.86,;25.59,-31.56,;24.9,-32.93,;25.37,-34.4,;24.34,-35.54,;22.81,-35.62,;22.89,-37.16,;24.43,-37.07,;23.52,-32.23,)| Show InChI InChI=1S/C29H28N6/c30-28-27-26(22-8-7-21-9-10-24(32-25(21)17-22)20-5-2-1-3-6-20)33-29(35(27)14-11-31-28)23-15-19(16-23)18-34-12-4-13-34/h1-3,5-11,14,17,19,23H,4,12-13,15-16,18H2,(H2,30,31)/t19-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375330
(CHEMBL408712)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@@H](C1)N1CCCCC1 |wU:26.30,28.35,(22.65,3.13,;22.66,1.59,;21.34,.82,;21.33,-.72,;22.66,-1.49,;24,-.72,;25.48,-1.2,;26.39,.05,;25.48,1.31,;26.25,2.63,;25.49,3.96,;26.26,5.29,;27.81,5.29,;28.57,6.63,;30.12,6.61,;30.9,5.28,;30.12,3.94,;28.57,3.95,;27.8,2.62,;32.44,5.27,;33.21,3.93,;34.75,3.93,;35.52,5.27,;34.74,6.61,;33.2,6.6,;24,.83,;25.96,-2.67,;25.26,-4.04,;26.64,-4.73,;27.33,-3.36,;27.11,-6.19,;26.22,-7.44,;26.85,-8.83,;28.38,-8.99,;29.27,-7.74,;28.64,-6.33,)| Show InChI InChI=1S/C30H30N6/c31-29-28-27(22-10-9-21-11-12-25(33-26(21)19-22)20-7-3-1-4-8-20)34-30(36(28)16-13-32-29)23-17-24(18-23)35-14-5-2-6-15-35/h1,3-4,7-13,16,19,23-24H,2,5-6,14-15,17-18H2,(H2,31,32)/t23-,24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199659
(CHEMBL392788 | US8481733, Comparator 1 | cis-3-(3-...)Show SMILES NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:4.6,2.1,(-3.93,-46.02,;-5.43,-45.7,;-5.91,-44.24,;-7.28,-43.54,;-6.58,-42.18,;-5.21,-42.87,;-7.06,-40.71,;-6.15,-39.45,;-7.06,-38.2,;-6.59,-36.73,;-7.62,-35.6,;-7.15,-34.14,;-5.64,-33.81,;-4.61,-34.96,;-3.1,-34.64,;-2.07,-35.78,;-.56,-35.46,;.46,-36.61,;1.96,-36.29,;2.44,-34.82,;1.4,-33.67,;-.1,-34,;-5.08,-36.42,;-8.54,-38.68,;-9.88,-37.92,;-9.88,-36.38,;-11.2,-38.69,;-11.2,-40.23,;-9.87,-41,;-8.54,-40.23,)| Show InChI InChI=1S/C24H25N5O/c25-14-17-11-19(12-17)24-28-21(22-23(26)27-9-10-29(22)24)18-7-4-8-20(13-18)30-15-16-5-2-1-3-6-16/h1-10,13,17,19H,11-12,14-15,25H2,(H2,26,27)/t17-,19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50336316
(CHEMBL410659 | cis-3-(3-(azetidin-1-ylmethyl)cyclo...)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@H](CN2CCC2)C1 |wU:26.30,28.33,(7.04,-25.52,;7.05,-27.06,;5.72,-27.83,;5.72,-29.37,;7.05,-30.15,;8.39,-29.37,;9.86,-29.85,;10.77,-28.6,;9.86,-27.34,;10.64,-26.02,;9.88,-24.69,;10.64,-23.36,;12.19,-23.36,;12.96,-22.02,;14.5,-22.04,;15.28,-23.37,;14.5,-24.71,;12.96,-24.7,;12.18,-26.03,;16.82,-23.38,;17.59,-24.72,;19.13,-24.72,;19.9,-23.38,;19.12,-22.05,;17.59,-22.05,;8.39,-27.82,;10.34,-31.32,;9.65,-32.69,;11.02,-33.38,;11.5,-34.85,;10.47,-35.99,;8.93,-36.07,;9.01,-37.61,;10.55,-37.53,;11.72,-32.01,)| Show InChI InChI=1S/C29H28N6/c30-28-27-26(22-8-7-21-9-10-24(32-25(21)17-22)20-5-2-1-3-6-20)33-29(35(27)14-11-31-28)23-15-19(16-23)18-34-12-4-13-34/h1-3,5-11,14,17,19,23H,4,12-13,15-16,18H2,(H2,30,31)/t19-,23+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human purified insulin receptor expressed in HepG2 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375341
(CHEMBL261146)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@@H](C1)N1CCCC1 |wU:26.30,28.35,(6.76,3.51,;6.77,1.97,;5.45,1.2,;5.44,-.35,;6.78,-1.12,;8.11,-.35,;9.59,-.83,;10.5,.43,;9.59,1.69,;10.36,3.01,;9.6,4.34,;10.37,5.67,;11.92,5.67,;12.68,7,;14.23,6.99,;15.01,5.65,;14.23,4.32,;12.68,4.32,;11.91,3,;16.55,5.65,;17.32,4.31,;18.86,4.31,;19.63,5.64,;18.85,6.98,;17.31,6.98,;8.11,1.21,;10.07,-2.29,;9.37,-3.66,;10.75,-4.36,;11.44,-2.98,;11.22,-5.82,;10.33,-7.06,;11.23,-8.31,;12.7,-7.83,;12.7,-6.29,)| Show InChI InChI=1S/C29H28N6/c30-28-27-26(21-9-8-20-10-11-24(32-25(20)18-21)19-6-2-1-3-7-19)33-29(35(27)15-12-31-28)22-16-23(17-22)34-13-4-5-14-34/h1-3,6-12,15,18,22-23H,4-5,13-14,16-17H2,(H2,30,31)/t22-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199661
(CHEMBL240035 | trans-3-(-4-(azetidin-1-ylmethyl)cy...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCC2)CC1 |wU:27.31,wD:24.27,(7.51,1.57,;7.52,.03,;6.19,-.74,;6.19,-2.29,;7.52,-3.06,;8.86,-2.29,;10.33,-2.77,;11.25,-1.51,;10.33,-.26,;10.81,1.21,;9.77,2.34,;10.24,3.8,;11.76,4.13,;12.79,2.99,;14.29,3.31,;15.32,2.16,;16.83,2.48,;17.85,1.34,;19.36,1.66,;19.83,3.12,;18.8,4.27,;17.29,3.94,;12.31,1.52,;8.86,-.74,;10.81,-4.23,;9.78,-5.38,;10.25,-6.84,;11.75,-7.17,;12.23,-8.63,;13.73,-8.96,;14.56,-10.26,;15.85,-9.42,;15.02,-8.13,;12.79,-6.02,;12.32,-4.55,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(24-8-4-9-25(18-24)35-20-22-6-2-1-3-7-22)32-29(34(27)17-14-31-28)23-12-10-21(11-13-23)19-33-15-5-16-33/h1-4,6-9,14,17-18,21,23H,5,10-13,15-16,19-20H2,(H2,30,31)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50339059
(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)C1CCC1 Show InChI InChI=1S/C25H21N5/c26-24-23-22(29-25(18-7-4-8-18)30(23)14-13-27-24)19-10-9-17-11-12-20(28-21(17)15-19)16-5-2-1-3-6-16/h1-3,5-6,9-15,18H,4,7-8H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199632
(CHEMBL239985 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,26.30,(25.65,-17.79,;25.65,-19.33,;24.33,-20.1,;24.33,-21.64,;25.66,-22.41,;27,-21.64,;28.47,-22.12,;29.38,-20.86,;28.47,-19.61,;28.95,-18.14,;27.91,-17.01,;28.38,-15.55,;29.89,-15.22,;30.93,-16.37,;32.43,-16.05,;33.46,-17.19,;34.97,-16.87,;35.99,-18.02,;37.5,-17.7,;37.97,-16.23,;36.93,-15.08,;35.43,-15.41,;30.45,-17.83,;26.99,-20.09,;28.95,-23.59,;28.25,-24.95,;29.62,-25.65,;30.1,-27.11,;31.6,-27.43,;32.23,-28.84,;33.77,-28.68,;34.09,-27.17,;32.75,-26.4,;30.32,-24.28,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199624
(CHEMBL392082 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCOCC2)CC1 |wU:27.31,wD:24.27,(-9.11,-17.4,;-9.11,-18.94,;-10.43,-19.71,;-10.45,-21.25,;-9.1,-22.03,;-7.77,-21.26,;-6.29,-21.74,;-5.38,-20.48,;-6.29,-19.22,;-5.82,-17.76,;-6.85,-16.63,;-6.38,-15.16,;-4.87,-14.84,;-3.84,-15.98,;-2.33,-15.66,;-1.3,-16.81,;.21,-16.49,;1.23,-17.63,;2.73,-17.31,;3.21,-15.84,;2.17,-14.7,;.67,-15.02,;-4.31,-17.45,;-7.77,-19.7,;-5.81,-23.2,;-6.85,-24.35,;-6.37,-25.81,;-4.87,-26.13,;-4.4,-27.6,;-2.89,-27.92,;-2.43,-29.39,;-.93,-29.71,;.11,-28.58,;-.36,-27.11,;-1.86,-26.77,;-3.84,-24.99,;-4.31,-23.52,)| Show InChI InChI=1S/C30H35N5O2/c31-29-28-27(25-7-4-8-26(19-25)37-21-23-5-2-1-3-6-23)33-30(35(28)14-13-32-29)24-11-9-22(10-12-24)20-34-15-17-36-18-16-34/h1-8,13-14,19,22,24H,9-12,15-18,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199623
(CHEMBL394155 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCCC2)CC1 |wU:27.31,wD:24.27,(25.91,1,;25.92,-.54,;24.59,-1.31,;24.59,-2.85,;25.92,-3.62,;27.26,-2.85,;28.74,-3.33,;29.65,-2.08,;28.74,-.82,;29.21,.64,;28.18,1.78,;28.65,3.24,;30.16,3.57,;31.19,2.42,;32.7,2.74,;33.73,1.6,;35.23,1.92,;36.26,.77,;37.76,1.09,;38.24,2.56,;37.2,3.7,;35.7,3.38,;30.71,.96,;27.26,-1.3,;29.21,-4.8,;28.18,-5.94,;28.65,-7.4,;30.16,-7.73,;30.63,-9.2,;32.13,-9.52,;32.76,-10.92,;34.29,-10.76,;34.62,-9.26,;33.29,-8.48,;31.19,-6.59,;30.72,-5.12,)| Show InChI InChI=1S/C30H35N5O/c31-29-28-27(25-9-6-10-26(19-25)36-21-23-7-2-1-3-8-23)33-30(35(28)18-15-32-29)24-13-11-22(12-14-24)20-34-16-4-5-17-34/h1-3,6-10,15,18-19,22,24H,4-5,11-14,16-17,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199668
(CHEMBL240034 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES CCN(CC)C[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.5,wD:9.12,(.11,-7.88,;-1.4,-7.56,;-2.43,-8.7,;-1.96,-10.17,;-.45,-10.49,;-3.94,-8.38,;-4.41,-6.91,;-5.91,-6.58,;-6.38,-5.12,;-5.35,-3.98,;-3.84,-4.29,;-3.37,-5.77,;-5.83,-2.51,;-4.92,-1.25,;-5.83,0,;-5.35,1.47,;-6.39,2.6,;-5.92,4.06,;-4.41,4.39,;-3.37,3.24,;-1.87,3.56,;-.84,2.42,;.67,2.74,;1.69,1.59,;3.2,1.91,;3.67,3.38,;2.63,4.53,;1.13,4.2,;-3.85,1.78,;-7.3,-.48,;-8.65,.28,;-8.65,1.82,;-9.97,-.49,;-9.97,-2.03,;-8.64,-2.8,;-7.3,-2.03,)| Show InChI InChI=1S/C30H37N5O/c1-3-34(4-2)20-22-13-15-24(16-14-22)30-33-27(28-29(31)32-17-18-35(28)30)25-11-8-12-26(19-25)36-21-23-9-6-5-7-10-23/h5-12,17-19,22,24H,3-4,13-16,20-21H2,1-2H3,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199666
(CHEMBL437558 | trans-1-(3-(benzyloxy)phenyl)-3-(3-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,wD:26.30,(8.59,-17.92,;8.59,-19.46,;7.27,-20.23,;7.27,-21.77,;8.6,-22.54,;9.94,-21.77,;11.41,-22.25,;12.32,-20.99,;11.41,-19.74,;11.89,-18.27,;10.85,-17.14,;11.32,-15.68,;12.83,-15.35,;13.87,-16.5,;15.37,-16.18,;16.4,-17.32,;17.91,-17,;18.93,-18.14,;20.44,-17.83,;20.91,-16.36,;19.87,-15.21,;18.37,-15.54,;13.39,-17.96,;9.94,-20.22,;11.89,-23.71,;13.26,-24.41,;12.56,-25.78,;13.04,-27.24,;14.55,-27.56,;15.17,-28.97,;16.71,-28.81,;17.03,-27.3,;15.69,-26.53,;11.19,-25.08,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199640
(CHEMBL392284 | trans3-(-4-(aminomethyl)cyclohexyl)...)Show SMILES NC[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:2.1,wD:5.8,(13.4,-48.47,;11.89,-48.15,;11.42,-46.68,;9.92,-46.36,;9.44,-44.9,;10.48,-43.75,;11.98,-44.07,;12.45,-45.54,;10,-42.29,;10.91,-41.03,;10,-39.77,;10.47,-38.31,;9.44,-37.18,;9.91,-35.71,;11.42,-35.39,;12.45,-36.53,;13.96,-36.21,;14.99,-37.36,;16.5,-37.04,;17.52,-38.18,;19.02,-37.86,;19.5,-36.39,;18.46,-35.25,;16.96,-35.57,;11.98,-38,;8.52,-40.25,;7.18,-39.49,;7.18,-37.95,;5.86,-40.26,;5.86,-41.81,;7.19,-42.58,;8.52,-41.81,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375340
(CHEMBL258951)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@@H](C1)N1CCSCC1 |wU:26.30,28.35,(-8.5,-13.48,;-8.49,-15.02,;-9.82,-15.79,;-9.82,-17.34,;-8.49,-18.11,;-7.15,-17.34,;-5.67,-17.82,;-4.76,-16.56,;-5.68,-15.31,;-4.9,-13.98,;-5.66,-12.65,;-4.89,-11.32,;-3.34,-11.32,;-2.58,-9.99,;-1.03,-10,;-.25,-11.34,;-1.03,-12.67,;-2.58,-12.67,;-3.36,-13.99,;1.28,-11.35,;2.05,-12.68,;3.59,-12.68,;4.36,-11.35,;3.59,-10.01,;2.05,-10.02,;-7.15,-15.79,;-5.2,-19.28,;-5.89,-20.65,;-4.52,-21.35,;-3.82,-19.98,;-4.04,-22.81,;-4.94,-24.06,;-4.31,-25.45,;-2.78,-25.6,;-1.88,-24.35,;-2.52,-22.95,)| Show InChI InChI=1S/C29H28N6S/c30-28-27-26(21-7-6-20-8-9-24(32-25(20)18-21)19-4-2-1-3-5-19)33-29(35(27)11-10-31-28)22-16-23(17-22)34-12-14-36-15-13-34/h1-11,18,22-23H,12-17H2,(H2,30,31)/t22-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375332
(CHEMBL411082)Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@@H](C1)N1CCC1 |wU:26.30,28.35,(-8.61,2.61,;-8.6,1.07,;-9.93,.3,;-9.93,-1.25,;-8.6,-2.02,;-7.26,-1.25,;-5.78,-1.72,;-4.87,-.47,;-5.79,.79,;-5.01,2.11,;-5.77,3.44,;-5,4.77,;-3.46,4.77,;-2.69,6.1,;-1.14,6.09,;-.37,4.76,;-1.15,3.42,;-2.69,3.43,;-3.47,2.1,;1.17,4.75,;1.94,3.41,;3.48,3.41,;4.25,4.75,;3.47,6.08,;1.94,6.08,;-7.26,.31,;-5.31,-3.19,;-6,-4.56,;-4.63,-5.26,;-3.93,-3.88,;-4.15,-6.72,;-4.85,-8.09,;-3.47,-8.79,;-2.78,-7.41,)| Show InChI InChI=1S/C28H26N6/c29-27-26-25(32-28(34(26)14-11-30-27)21-15-22(16-21)33-12-4-13-33)20-8-7-19-9-10-23(31-24(19)17-20)18-5-2-1-3-6-18/h1-3,5-11,14,17,21-22H,4,12-13,15-16H2,(H2,29,30)/t21-,22+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199686
(CHEMBL393314 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(m...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCOCC2)C1 |wU:24.27,26.30,(-9.93,2.7,;-9.92,1.16,;-11.25,.39,;-11.25,-1.15,;-9.92,-1.92,;-8.58,-1.15,;-7.1,-1.63,;-6.19,-.37,;-7.1,.88,;-6.63,2.35,;-7.66,3.48,;-7.19,4.94,;-5.68,5.27,;-4.65,4.12,;-3.14,4.44,;-2.11,3.3,;-.61,3.62,;.42,2.48,;1.92,2.79,;2.4,4.26,;1.36,5.41,;-.14,5.08,;-5.12,2.66,;-8.58,.4,;-6.63,-3.09,;-7.33,-4.46,;-5.95,-5.16,;-5.48,-6.62,;-3.97,-6.94,;-3.51,-8.41,;-2.01,-8.73,;-.97,-7.59,;-1.44,-6.12,;-2.95,-5.8,;-5.26,-3.79,)| Show InChI InChI=1S/C28H31N5O2/c29-27-26-25(22-7-4-8-24(17-22)35-19-20-5-2-1-3-6-20)31-28(33(26)10-9-30-27)23-15-21(16-23)18-32-11-13-34-14-12-32/h1-10,17,21,23H,11-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50375333
(CHEMBL430051)Show SMILES CN(C)[C@H]1C[C@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |wU:5.7,3.2,(24.37,-53.29,;25.4,-52.15,;26.9,-52.47,;24.92,-50.68,;23.55,-49.98,;24.24,-48.62,;25.62,-49.31,;23.77,-47.15,;24.68,-45.9,;23.76,-44.64,;24.54,-43.32,;23.78,-41.99,;24.55,-40.66,;26.09,-40.66,;26.86,-39.32,;28.4,-39.34,;29.18,-40.67,;28.4,-42.01,;26.86,-42,;26.08,-43.33,;30.72,-40.68,;31.49,-42.02,;33.03,-42.02,;33.8,-40.68,;33.02,-39.34,;31.49,-39.35,;22.29,-45.12,;20.95,-44.36,;20.94,-42.82,;19.62,-45.13,;19.62,-46.67,;20.95,-47.44,;22.29,-46.67,)| Show InChI InChI=1S/C27H26N6/c1-32(2)21-14-20(15-21)27-31-24(25-26(28)29-12-13-33(25)27)19-9-8-18-10-11-22(30-23(18)16-19)17-6-4-3-5-7-17/h3-13,16,20-21H,14-15H2,1-2H3,(H2,28,29)/t20-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells |
Bioorg Med Chem 16: 1359-75 (2008)
Article DOI: 10.1016/j.bmc.2007.10.061
BindingDB Entry DOI: 10.7270/Q2WH2QVH |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199626
(CHEMBL401429 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CN(C)C[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.8,4.3,(13.74,-47.62,;13.26,-46.15,;14.29,-45.01,;11.76,-45.84,;11.28,-44.37,;9.91,-43.67,;10.61,-42.31,;11.98,-43,;10.13,-40.84,;11.04,-39.59,;10.13,-38.33,;10.6,-36.87,;9.57,-35.73,;10.04,-34.27,;11.55,-33.94,;12.58,-35.09,;14.09,-34.77,;15.12,-35.91,;16.63,-35.59,;17.65,-36.74,;19.15,-36.42,;19.63,-34.95,;18.59,-33.8,;17.09,-34.13,;12.11,-36.55,;8.65,-38.81,;7.31,-38.05,;7.3,-36.51,;5.99,-38.82,;5.98,-40.36,;7.31,-41.13,;8.65,-40.36,)| Show InChI InChI=1S/C26H29N5O/c1-30(2)16-19-13-21(14-19)26-29-23(24-25(27)28-11-12-31(24)26)20-9-6-10-22(15-20)32-17-18-7-4-3-5-8-18/h3-12,15,19,21H,13-14,16-17H2,1-2H3,(H2,27,28)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199626
(CHEMBL401429 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CN(C)C[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.8,4.3,(13.74,-47.62,;13.26,-46.15,;14.29,-45.01,;11.76,-45.84,;11.28,-44.37,;9.91,-43.67,;10.61,-42.31,;11.98,-43,;10.13,-40.84,;11.04,-39.59,;10.13,-38.33,;10.6,-36.87,;9.57,-35.73,;10.04,-34.27,;11.55,-33.94,;12.58,-35.09,;14.09,-34.77,;15.12,-35.91,;16.63,-35.59,;17.65,-36.74,;19.15,-36.42,;19.63,-34.95,;18.59,-33.8,;17.09,-34.13,;12.11,-36.55,;8.65,-38.81,;7.31,-38.05,;7.3,-36.51,;5.99,-38.82,;5.98,-40.36,;7.31,-41.13,;8.65,-40.36,)| Show InChI InChI=1S/C26H29N5O/c1-30(2)16-19-13-21(14-19)26-29-23(24-25(27)28-11-12-31(24)26)20-9-6-10-22(15-20)32-17-18-7-4-3-5-8-18/h3-12,15,19,21H,13-14,16-17H2,1-2H3,(H2,27,28)/t19-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 191 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199641
(1-(3-(2,6-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4c(F)cccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-18-8-3-9-19(25)17(18)13-30-16-7-2-6-15(12-16)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 215 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199650
(CHEMBL240613 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CC(C)NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:7.9,5.4,(15.38,-7.53,;13.87,-7.21,;13.4,-5.74,;12.84,-8.35,;11.34,-8.03,;10.86,-6.57,;9.49,-5.87,;10.19,-4.51,;11.56,-5.2,;9.71,-3.04,;10.62,-1.79,;9.71,-.53,;10.18,.93,;9.15,2.07,;9.62,3.53,;11.13,3.86,;12.16,2.71,;13.67,3.03,;14.7,1.89,;16.21,2.21,;17.23,1.06,;18.73,1.38,;19.21,2.85,;18.17,4,;16.67,3.67,;11.69,1.25,;8.23,-1.01,;6.89,-.25,;6.88,1.29,;5.57,-1.02,;5.56,-2.56,;6.9,-3.33,;8.23,-2.56,)| Show InChI InChI=1S/C27H31N5O/c1-18(2)30-16-20-13-22(14-20)27-31-24(25-26(28)29-11-12-32(25)27)21-9-6-10-23(15-21)33-17-19-7-4-3-5-8-19/h3-12,15,18,20,22,30H,13-14,16-17H2,1-2H3,(H2,28,29)/t20-,22+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199630
(1-(3-(2-fluorobenzyloxy)phenyl)-3-cyclobutylimidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H21FN4O/c24-19-10-2-1-5-17(19)14-29-18-9-4-8-16(13-18)20-21-22(25)26-11-12-28(21)23(27-20)15-6-3-7-15/h1-2,4-5,8-13,15H,3,6-7,14H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199631
(CHEMBL394154 | cis-3-(4-(aminomethyl)cyclohexyl)-1...)Show SMILES NC[C@H]1CC[C@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:5.8,2.1,(30.07,-50.41,;28.57,-50.08,;28.1,-48.62,;26.59,-48.29,;26.12,-46.83,;27.15,-45.68,;28.66,-46,;29.13,-47.47,;26.68,-44.22,;27.59,-42.96,;26.67,-41.71,;27.15,-40.24,;26.12,-39.11,;26.58,-37.65,;28.1,-37.32,;29.13,-38.47,;30.63,-38.15,;31.66,-39.29,;33.17,-38.97,;34.19,-40.11,;35.7,-39.79,;36.18,-38.33,;35.14,-37.18,;33.63,-37.51,;28.65,-39.93,;25.2,-42.19,;23.86,-41.43,;23.85,-39.89,;22.53,-42.2,;22.53,-43.74,;23.86,-44.51,;25.2,-43.74,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199638
(CHEMBL393313 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCCC2)C1 |wU:24.27,26.30,(24.76,-37.15,;24.77,-38.69,;23.45,-39.46,;23.44,-41,;24.78,-41.77,;26.11,-41,;27.59,-41.48,;28.5,-40.22,;27.59,-38.97,;28.06,-37.5,;27.03,-36.37,;27.5,-34.91,;29.01,-34.58,;30.04,-35.73,;31.55,-35.41,;32.58,-36.55,;34.09,-36.23,;35.11,-37.38,;36.61,-37.06,;37.09,-35.59,;36.05,-34.44,;34.55,-34.77,;29.57,-37.19,;26.11,-39.45,;28.07,-42.94,;27.37,-44.31,;28.74,-45.01,;29.22,-46.47,;30.72,-46.79,;31.19,-48.26,;32.69,-48.58,;33.72,-47.44,;33.25,-45.97,;31.74,-45.65,;29.44,-43.64,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(23-10-7-11-25(18-23)35-20-21-8-3-1-4-9-21)32-29(34(27)15-12-31-28)24-16-22(17-24)19-33-13-5-2-6-14-33/h1,3-4,7-12,15,18,22,24H,2,5-6,13-14,16-17,19-20H2,(H2,30,31)/t22-,24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 237 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199676
(1-(3-(2-chloro-6-fluorobenzyloxy)phenyl)-3-cyclobu...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4c(F)cccc4Cl)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20ClFN4O/c24-18-8-3-9-19(25)17(18)13-30-16-7-2-6-15(12-16)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 248 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199665
(1-(3-(2,5-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cc(F)ccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-17-7-8-19(25)16(11-17)13-30-18-6-2-5-15(12-18)20-21-22(26)27-9-10-29(21)23(28-20)14-3-1-4-14/h2,5-12,14H,1,3-4,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 329 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199665
(1-(3-(2,5-difluorobenzyloxy)phenyl)-3-cyclobutylim...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cc(F)ccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-17-7-8-19(25)16(11-17)13-30-18-6-2-5-15(12-18)20-21-22(26)27-9-10-29(21)23(28-20)14-3-1-4-14/h2,5-12,14H,1,3-4,13H2,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 329 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199689
(1-(3-(2-chlorobenzyloxy)phenyl)-3-cyclobutylimidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4Cl)c3)c12)C1CCC1 Show InChI InChI=1S/C23H21ClN4O/c24-19-10-2-1-5-17(19)14-29-18-9-4-8-16(13-18)20-21-22(25)26-11-12-28(21)23(27-20)15-6-3-7-15/h1-2,4-5,8-13,15H,3,6-7,14H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 343 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199638
(CHEMBL393313 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCCC2)C1 |wU:24.27,26.30,(24.76,-37.15,;24.77,-38.69,;23.45,-39.46,;23.44,-41,;24.78,-41.77,;26.11,-41,;27.59,-41.48,;28.5,-40.22,;27.59,-38.97,;28.06,-37.5,;27.03,-36.37,;27.5,-34.91,;29.01,-34.58,;30.04,-35.73,;31.55,-35.41,;32.58,-36.55,;34.09,-36.23,;35.11,-37.38,;36.61,-37.06,;37.09,-35.59,;36.05,-34.44,;34.55,-34.77,;29.57,-37.19,;26.11,-39.45,;28.07,-42.94,;27.37,-44.31,;28.74,-45.01,;29.22,-46.47,;30.72,-46.79,;31.19,-48.26,;32.69,-48.58,;33.72,-47.44,;33.25,-45.97,;31.74,-45.65,;29.44,-43.64,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(23-10-7-11-25(18-23)35-20-21-8-3-1-4-9-21)32-29(34(27)15-12-31-28)24-16-22(17-24)19-33-13-5-2-6-14-33/h1,3-4,7-12,15,18,22,24H,2,5-6,13-14,16-17,19-20H2,(H2,30,31)/t22-,24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 346 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199650
(CHEMBL240613 | cis-1-(3-(benzyloxy)phenyl)-3-(3-((...)Show SMILES CC(C)NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:7.9,5.4,(15.38,-7.53,;13.87,-7.21,;13.4,-5.74,;12.84,-8.35,;11.34,-8.03,;10.86,-6.57,;9.49,-5.87,;10.19,-4.51,;11.56,-5.2,;9.71,-3.04,;10.62,-1.79,;9.71,-.53,;10.18,.93,;9.15,2.07,;9.62,3.53,;11.13,3.86,;12.16,2.71,;13.67,3.03,;14.7,1.89,;16.21,2.21,;17.23,1.06,;18.73,1.38,;19.21,2.85,;18.17,4,;16.67,3.67,;11.69,1.25,;8.23,-1.01,;6.89,-.25,;6.88,1.29,;5.57,-1.02,;5.56,-2.56,;6.9,-3.33,;8.23,-2.56,)| Show InChI InChI=1S/C27H31N5O/c1-18(2)30-16-20-13-22(14-20)27-31-24(25-26(28)29-11-12-32(25)27)21-9-6-10-23(15-21)33-17-19-7-4-3-5-8-19/h3-12,15,18,20,22,30H,13-14,16-17H2,1-2H3,(H2,28,29)/t20-,22+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 376 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199661
(CHEMBL240035 | trans-3-(-4-(azetidin-1-ylmethyl)cy...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCC2)CC1 |wU:27.31,wD:24.27,(7.51,1.57,;7.52,.03,;6.19,-.74,;6.19,-2.29,;7.52,-3.06,;8.86,-2.29,;10.33,-2.77,;11.25,-1.51,;10.33,-.26,;10.81,1.21,;9.77,2.34,;10.24,3.8,;11.76,4.13,;12.79,2.99,;14.29,3.31,;15.32,2.16,;16.83,2.48,;17.85,1.34,;19.36,1.66,;19.83,3.12,;18.8,4.27,;17.29,3.94,;12.31,1.52,;8.86,-.74,;10.81,-4.23,;9.78,-5.38,;10.25,-6.84,;11.75,-7.17,;12.23,-8.63,;13.73,-8.96,;14.56,-10.26,;15.85,-9.42,;15.02,-8.13,;12.79,-6.02,;12.32,-4.55,)| Show InChI InChI=1S/C29H33N5O/c30-28-27-26(24-8-4-9-25(18-24)35-20-22-6-2-1-3-7-22)32-29(34(27)17-14-31-28)23-12-10-21(11-13-23)19-33-15-5-16-33/h1-4,6-9,14,17-18,21,23H,5,10-13,15-16,19-20H2,(H2,30,31)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199632
(CHEMBL239985 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(p...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,26.30,(25.65,-17.79,;25.65,-19.33,;24.33,-20.1,;24.33,-21.64,;25.66,-22.41,;27,-21.64,;28.47,-22.12,;29.38,-20.86,;28.47,-19.61,;28.95,-18.14,;27.91,-17.01,;28.38,-15.55,;29.89,-15.22,;30.93,-16.37,;32.43,-16.05,;33.46,-17.19,;34.97,-16.87,;35.99,-18.02,;37.5,-17.7,;37.97,-16.23,;36.93,-15.08,;35.43,-15.41,;30.45,-17.83,;26.99,-20.09,;28.95,-23.59,;28.25,-24.95,;29.62,-25.65,;30.1,-27.11,;31.6,-27.43,;32.23,-28.84,;33.77,-28.68,;34.09,-27.17,;32.75,-26.4,;30.32,-24.28,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 401 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199668
(CHEMBL240034 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES CCN(CC)C[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:6.5,wD:9.12,(.11,-7.88,;-1.4,-7.56,;-2.43,-8.7,;-1.96,-10.17,;-.45,-10.49,;-3.94,-8.38,;-4.41,-6.91,;-5.91,-6.58,;-6.38,-5.12,;-5.35,-3.98,;-3.84,-4.29,;-3.37,-5.77,;-5.83,-2.51,;-4.92,-1.25,;-5.83,0,;-5.35,1.47,;-6.39,2.6,;-5.92,4.06,;-4.41,4.39,;-3.37,3.24,;-1.87,3.56,;-.84,2.42,;.67,2.74,;1.69,1.59,;3.2,1.91,;3.67,3.38,;2.63,4.53,;1.13,4.2,;-3.85,1.78,;-7.3,-.48,;-8.65,.28,;-8.65,1.82,;-9.97,-.49,;-9.97,-2.03,;-8.64,-2.8,;-7.3,-2.03,)| Show InChI InChI=1S/C30H37N5O/c1-3-34(4-2)20-22-13-15-24(16-14-22)30-33-27(28-29(31)32-17-18-35(28)30)25-11-8-12-26(19-25)36-21-23-9-6-5-7-10-23/h5-12,17-19,22,24H,3-4,13-16,20-21H2,1-2H3,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199625
(1-(3-(3-fluorobenzyloxy)phenyl)-3-cyclobutylimidaz...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4cccc(F)c4)c3)c12)C1CCC1 Show InChI InChI=1S/C23H21FN4O/c24-18-8-1-4-15(12-18)14-29-19-9-3-7-17(13-19)20-21-22(25)26-10-11-28(21)23(27-20)16-5-2-6-16/h1,3-4,7-13,16H,2,5-6,14H2,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199683
(3-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)...)Show InChI InChI=1S/C16H16N4O/c17-15-14-13(11-5-2-6-12(21)9-11)19-16(10-3-1-4-10)20(14)8-7-18-15/h2,5-10,21H,1,3-4H2,(H2,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 518 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199629
(CHEMBL393517 | trans-3-(8-amino-1-(3-(benzyloxy)ph...)Show SMILES NC(=O)[C@H]1C[C@@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:5.7,wD:3.2,(-3.43,-24.86,;-4.94,-24.54,;-5.97,-25.68,;-5.41,-23.07,;-4.72,-21.7,;-6.09,-21.01,;-6.79,-22.38,;-6.56,-19.55,;-5.65,-18.29,;-6.56,-17.03,;-6.09,-15.57,;-7.12,-14.44,;-6.66,-12.97,;-5.14,-12.65,;-4.11,-13.79,;-2.6,-13.47,;-1.57,-14.62,;-.07,-14.3,;.96,-15.44,;2.46,-15.12,;2.94,-13.66,;1.9,-12.51,;.4,-12.83,;-4.59,-15.26,;-8.04,-17.52,;-9.38,-16.75,;-9.39,-15.21,;-10.71,-17.52,;-10.71,-19.07,;-9.38,-19.84,;-8.04,-19.07,)| Show InChI InChI=1S/C24H23N5O2/c25-22-21-20(16-7-4-8-19(13-16)31-14-15-5-2-1-3-6-15)28-24(29(21)10-9-27-22)18-11-17(12-18)23(26)30/h1-10,13,17-18H,11-12,14H2,(H2,25,27)(H2,26,30)/t17-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 526 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199640
(CHEMBL392284 | trans3-(-4-(aminomethyl)cyclohexyl)...)Show SMILES NC[C@H]1CC[C@@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:2.1,wD:5.8,(13.4,-48.47,;11.89,-48.15,;11.42,-46.68,;9.92,-46.36,;9.44,-44.9,;10.48,-43.75,;11.98,-44.07,;12.45,-45.54,;10,-42.29,;10.91,-41.03,;10,-39.77,;10.47,-38.31,;9.44,-37.18,;9.91,-35.71,;11.42,-35.39,;12.45,-36.53,;13.96,-36.21,;14.99,-37.36,;16.5,-37.04,;17.52,-38.18,;19.02,-37.86,;19.5,-36.39,;18.46,-35.25,;16.96,-35.57,;11.98,-38,;8.52,-40.25,;7.18,-39.49,;7.18,-37.95,;5.86,-40.26,;5.86,-41.81,;7.19,-42.58,;8.52,-41.81,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 534 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199623
(CHEMBL394155 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCCC2)CC1 |wU:27.31,wD:24.27,(25.91,1,;25.92,-.54,;24.59,-1.31,;24.59,-2.85,;25.92,-3.62,;27.26,-2.85,;28.74,-3.33,;29.65,-2.08,;28.74,-.82,;29.21,.64,;28.18,1.78,;28.65,3.24,;30.16,3.57,;31.19,2.42,;32.7,2.74,;33.73,1.6,;35.23,1.92,;36.26,.77,;37.76,1.09,;38.24,2.56,;37.2,3.7,;35.7,3.38,;30.71,.96,;27.26,-1.3,;29.21,-4.8,;28.18,-5.94,;28.65,-7.4,;30.16,-7.73,;30.63,-9.2,;32.13,-9.52,;32.76,-10.92,;34.29,-10.76,;34.62,-9.26,;33.29,-8.48,;31.19,-6.59,;30.72,-5.12,)| Show InChI InChI=1S/C30H35N5O/c31-29-28-27(25-9-6-10-26(19-25)36-21-23-7-2-1-3-8-23)33-30(35(28)18-15-32-29)24-13-11-22(12-14-24)20-34-16-4-5-17-34/h1-3,6-10,15,18-19,22,24H,4-5,11-14,16-17,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 547 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199631
(CHEMBL394154 | cis-3-(4-(aminomethyl)cyclohexyl)-1...)Show SMILES NC[C@H]1CC[C@H](CC1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12 |wU:5.8,2.1,(30.07,-50.41,;28.57,-50.08,;28.1,-48.62,;26.59,-48.29,;26.12,-46.83,;27.15,-45.68,;28.66,-46,;29.13,-47.47,;26.68,-44.22,;27.59,-42.96,;26.67,-41.71,;27.15,-40.24,;26.12,-39.11,;26.58,-37.65,;28.1,-37.32,;29.13,-38.47,;30.63,-38.15,;31.66,-39.29,;33.17,-38.97,;34.19,-40.11,;35.7,-39.79,;36.18,-38.33,;35.14,-37.18,;33.63,-37.51,;28.65,-39.93,;25.2,-42.19,;23.86,-41.43,;23.85,-39.89,;22.53,-42.2,;22.53,-43.74,;23.86,-44.51,;25.2,-43.74,)| Show InChI InChI=1S/C26H29N5O/c27-16-18-9-11-20(12-10-18)26-30-23(24-25(28)29-13-14-31(24)26)21-7-4-8-22(15-21)32-17-19-5-2-1-3-6-19/h1-8,13-15,18,20H,9-12,16-17,27H2,(H2,28,29)/t18-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM1779
(CHEMBL392106 | US8481733, Comparator 2)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)C1CCC1 Show InChI InChI=1S/C23H22N4O/c24-22-21-20(26-23(17-8-4-9-17)27(21)13-12-25-22)18-10-5-11-19(14-18)28-15-16-6-2-1-3-7-16/h1-3,5-7,10-14,17H,4,8-9,15H2,(H2,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 606 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199666
(CHEMBL437558 | trans-1-(3-(benzyloxy)phenyl)-3-(3-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCCC2)C1 |wU:24.27,wD:26.30,(8.59,-17.92,;8.59,-19.46,;7.27,-20.23,;7.27,-21.77,;8.6,-22.54,;9.94,-21.77,;11.41,-22.25,;12.32,-20.99,;11.41,-19.74,;11.89,-18.27,;10.85,-17.14,;11.32,-15.68,;12.83,-15.35,;13.87,-16.5,;15.37,-16.18,;16.4,-17.32,;17.91,-17,;18.93,-18.14,;20.44,-17.83,;20.91,-16.36,;19.87,-15.21,;18.37,-15.54,;13.39,-17.96,;9.94,-20.22,;11.89,-23.71,;13.26,-24.41,;12.56,-25.78,;13.04,-27.24,;14.55,-27.56,;15.17,-28.97,;16.71,-28.81,;17.03,-27.3,;15.69,-26.53,;11.19,-25.08,)| Show InChI InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(17-22)34-19-20-7-2-1-3-8-20)31-28(33(26)14-11-30-27)23-15-21(16-23)18-32-12-4-5-13-32/h1-3,6-11,14,17,21,23H,4-5,12-13,15-16,18-19H2,(H2,29,30)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 621 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199624
(CHEMBL392082 | trans-1-(3-(benzyloxy)phenyl)-3-(4-...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@H](CN2CCOCC2)CC1 |wU:27.31,wD:24.27,(-9.11,-17.4,;-9.11,-18.94,;-10.43,-19.71,;-10.45,-21.25,;-9.1,-22.03,;-7.77,-21.26,;-6.29,-21.74,;-5.38,-20.48,;-6.29,-19.22,;-5.82,-17.76,;-6.85,-16.63,;-6.38,-15.16,;-4.87,-14.84,;-3.84,-15.98,;-2.33,-15.66,;-1.3,-16.81,;.21,-16.49,;1.23,-17.63,;2.73,-17.31,;3.21,-15.84,;2.17,-14.7,;.67,-15.02,;-4.31,-17.45,;-7.77,-19.7,;-5.81,-23.2,;-6.85,-24.35,;-6.37,-25.81,;-4.87,-26.13,;-4.4,-27.6,;-2.89,-27.92,;-2.43,-29.39,;-.93,-29.71,;.11,-28.58,;-.36,-27.11,;-1.86,-26.77,;-3.84,-24.99,;-4.31,-23.52,)| Show InChI InChI=1S/C30H35N5O2/c31-29-28-27(25-7-4-8-26(19-25)37-21-23-5-2-1-3-6-23)33-30(35(28)14-13-32-29)24-11-9-22(10-12-24)20-34-15-17-36-18-16-34/h1-8,13-14,19,22,24H,9-12,15-18,20-21H2,(H2,31,32)/t22-,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 651 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199686
(CHEMBL393314 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(m...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCOCC2)C1 |wU:24.27,26.30,(-9.93,2.7,;-9.92,1.16,;-11.25,.39,;-11.25,-1.15,;-9.92,-1.92,;-8.58,-1.15,;-7.1,-1.63,;-6.19,-.37,;-7.1,.88,;-6.63,2.35,;-7.66,3.48,;-7.19,4.94,;-5.68,5.27,;-4.65,4.12,;-3.14,4.44,;-2.11,3.3,;-.61,3.62,;.42,2.48,;1.92,2.79,;2.4,4.26,;1.36,5.41,;-.14,5.08,;-5.12,2.66,;-8.58,.4,;-6.63,-3.09,;-7.33,-4.46,;-5.95,-5.16,;-5.48,-6.62,;-3.97,-6.94,;-3.51,-8.41,;-2.01,-8.73,;-.97,-7.59,;-1.44,-6.12,;-2.95,-5.8,;-5.26,-3.79,)| Show InChI InChI=1S/C28H31N5O2/c29-27-26-25(22-7-4-8-24(17-22)35-19-20-5-2-1-3-6-20)31-28(33(26)10-9-30-27)23-15-21(16-23)18-32-11-13-34-14-12-32/h1-10,17,21,23H,11-16,18-19H2,(H2,29,30)/t21-,23+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 658 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this
Ligand-Target Pair | |
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