| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
|---|
| Ligand | BDBM50614699 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2298657 |
|---|
| IC50 | 1800±n/a nM |
|---|
| Citation |  Markwalder, JA; Balog, AJ; Williams, DK; Nara, SJ; Reddy, R; Roy, S; Kanyaboina, Y; Li, X; Johnston, K; Fan, Y; Lewis, H; Marsilio, F; Yan, C; Critton, D; Newitt, JA; Traeger, SC; Wu, DR; Jure-Kunkel, MN; Jayaraman, L; Lin, TA; Sinz, MW; Hunt, JT; Seitz, SP Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1. Bioorg Med Chem Lett88:0 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C9 |
|---|
| Name: | Cytochrome P450 2C9 |
|---|
| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55636.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11712 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
|
|
|
|---|
| BDBM50614699 |
|---|
| n/a |
|---|
| Name | BDBM50614699 |
|---|
| Synonyms: | CHEMBL5267732 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H32N6O2 |
|---|
| Mol. Mass. | 484.5927 |
|---|
| SMILES | CCCC(CCC)Oc1ccc(cc1NC(=O)Nc1ccc(C)cc1)-c1ccccc1-c1nn[nH]n1 |
|---|
| Structure | 
|
|---|
Search and Browse
