| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
|---|
| Ligand | BDBM50206840 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_454785 (CHEMBL886813) |
|---|
| IC50 | 4420±n/a nM |
|---|
| Citation |  Eary, CT; Jones, ZS; Groneberg, RD; Burgess, LE; Mareska, DA; Drew, MD; Blake, JF; Laird, ER; Balachari, D; O'Sullivan, M; Allen, A; Marsh, V Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett17:2608-13 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholesteryl ester transfer protein |
|---|
| Name: | Cholesteryl ester transfer protein |
|---|
| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11597 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
|---|
| BDBM50206840 |
|---|
| n/a |
|---|
| Name | BDBM50206840 |
|---|
| Synonyms: | CHEMBL413002 | ethyl 4-((3,5-bis(trifluoromethyl)phenyl)(2-(3-methoxy-3-oxopropyl)-2H-tetrazol-5-yl)methyl)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27F9N6O4 |
|---|
| Mol. Mass. | 682.5374 |
|---|
| SMILES | CCOC(=O)N1C(CC)CN(C(c2nnn(CCC(=O)OC)n2)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2cc(ccc12)C(F)(F)F |w:11.10,6.6| |
|---|
| Structure | 
|
|---|
Search and Browse
