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TargetHydroxycarboxylic acid receptor 2
LigandBDBM50216550
Substrate/Competitorn/a
Meas. Tech.ChEMBL_456679
EC50 6200±n/a nM
Citation Gharbaoui TSkinner PJShin YJAverbuj CJung JKJohnson BRDuong TDecaire MUy JCherrier MCWebb PJTamura SYZou NRodriguez NBoatman PDSage CRLindstrom AXu JSchrader TOSmith BMChen RRichman JGConnolly DTColletti SLTata JRSemple G Agonist lead identification for the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett 17:4914-9 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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  Blast E-value cutoff:
BDBM50216550
n/a
NameBDBM50216550
Synonyms:3-(3-chlorobenzyl)-1H-pyrazole-5-carboxylic acid | 5-(3-Chloro-benzyl)-1H-pyrazole-3-carboxylic acid | 5-meta-chlorobenzyl-3-carboxyl-pyrazole | CHEMBL394441
TypeSmall organic molecule
Emp. Form.C11H9ClN2O2
Mol. Mass.236.654
SMILESOC(=O)c1cc(Cc2cccc(Cl)c2)[nH]n1
Structure
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