Reaction Details |
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Target | Thymidine kinase |
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Ligand | BDBM50217795 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_444706 (CHEMBL894947) |
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IC50 | 493000±n/a nM |
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Citation | Robins, MJ; Nowak, I; Rajwanshi, VK; Miranda, K; Cannon, JF; Peterson, MA; Andrei, G; Snoeck, R; De Clercq, E; Balzarini, J Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core. J Med Chem50:3897-905 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine kinase |
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Name: | Thymidine kinase |
Synonyms: | KITH_VZVD | TK |
Type: | PROTEIN |
Mol. Mass.: | 37819.99 |
Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
Description: | ChEMBL_444706 |
Residue: | 341 |
Sequence: | MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
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BDBM50217795 |
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n/a |
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Name | BDBM50217795 |
Synonyms: | 3-(2-deoxy-beta-d-erythro-pentofuranosyl)-6-(phenylethynyl)-furo[2,3-d]pyrimidin-2(3H)-one | CHEMBL243988 |
Type | Small organic molecule |
Emp. Form. | C19H16N2O5 |
Mol. Mass. | 352.3407 |
SMILES | OC[C@H]1O[C@H](C[C@@H]1O)n1cc2cc(oc2nc1=O)C#Cc1ccccc1 |
Structure |
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