Reaction Details |
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Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Ligand | BDBM50219275 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_457132 (CHEMBL940741) |
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IC50 | 600±n/a nM |
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Citation | Kuang, R; Shue, HJ; Blythin, DJ; Shih, NY; Gu, D; Chen, X; Schwerdt, J; Lin, L; Ting, PC; Zhu, X; Aslanian, R; Piwinski, JJ; Xiao, L; Prelusky, D; Wu, P; Zhang, J; Zhang, X; Celly, CS; Minnicozzi, M; Billah, M; Wang, P Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors. Bioorg Med Chem Lett17:5150-4 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
Type: | Enzyme |
Mol. Mass.: | 104751.53 |
Organism: | Homo sapiens (Human) |
Description: | Q9HCR9 |
Residue: | 933 |
Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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BDBM50219275 |
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n/a |
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Name | BDBM50219275 |
Synonyms: | CHEMBL249691 | tert-butyl 4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)oxazole-4-carbonyl)piperazine-1-carboxylate |
Type | Small organic molecule |
Emp. Form. | C25H28F3N5O5 |
Mol. Mass. | 535.5155 |
SMILES | COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F |
Structure |
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