Found 55 hits Enz. Inhib. hit(s) with all data for entry = 50020944 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219278
(CHEMBL250137 | [5-aminomethyl-2-(8-methoxy-2-trifl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N7O4/c1-13-11-16(33-32-13)23(36)34-7-9-35(10-8-34)24(37)21-18(12-29)39-22(31-21)15-3-5-17(38-2)20-14(15)4-6-19(30-20)25(26,27)28/h3-6,11H,7-10,12,29H2,1-2H3,(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219281
(CHEMBL399385 | [5-aminomethyl-2-(8-methoxy-2-trifl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3ccccn3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C26H23F3N6O4/c1-38-18-7-5-16(15-6-8-20(26(27,28)29)32-21(15)18)23-33-22(19(14-30)39-23)25(37)35-12-10-34(11-13-35)24(36)17-4-2-3-9-31-17/h2-9H,10-14,30H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219274
(8-[5-aminomethyl-2-(8-methoxy-2-trifluoromethyl-qu...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCC4(CC3)N(CNC4=O)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C29H27F3N6O4/c1-41-20-9-7-19(18-8-10-22(29(30,31)32)35-23(18)20)25-36-24(21(15-33)42-25)26(39)37-13-11-28(12-14-37)27(40)34-16-38(28)17-5-3-2-4-6-17/h2-10H,11-16,33H2,1H3,(H,34,40) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219277
(4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)S(=O)(=O)N(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C22H25F3N6O5S/c1-29(2)37(33,34)31-10-8-30(9-11-31)21(32)19-16(12-26)36-20(28-19)14-4-6-15(35-3)18-13(14)5-7-17(27-18)22(23,24)25/h4-7H,8-12,26H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219268
(CHEMBL399298 | tert-butyl (R)-1-(5-(aminomethyl)-2...)Show SMILES COc1ccc(-c2nc(C(=O)N3CC[C@H](C3)NC(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)30-13-9-10-33(12-13)22(34)20-17(11-29)37-21(32-20)15-5-7-16(36-4)19-14(15)6-8-18(31-19)25(26,27)28/h5-8,13H,9-12,29H2,1-4H3,(H,30,35)/t13-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219273
((Z)-(5-(aminomethyl)-2-(8-methoxy-2-(trifluorometh...)Show SMILES CO\N=C(\C1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F)c1ccccn1 Show InChI InChI=1S/C28H27F3N6O4/c1-39-20-8-6-18(17-7-9-22(28(29,30)31)34-24(17)20)26-35-25(21(15-32)41-26)27(38)37-13-10-16(11-14-37)23(36-40-2)19-5-3-4-12-33-19/h3-9,12,16H,10-11,13-15,32H2,1-2H3/b36-23- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219272
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCC(O)(CC3)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C27H25F3N4O4/c1-37-19-9-7-18(17-8-10-21(27(28,29)30)32-22(17)19)24-33-23(20(15-31)38-24)25(35)34-13-11-26(36,12-14-34)16-5-3-2-4-6-16/h2-10,36H,11-15,31H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219269
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C26H26F3N7O5/c1-38-16-6-4-15(14-5-7-18(26(27,28)29)31-21(14)16)23-34-22(17(13-30)41-23)24(37)35-8-10-36(11-9-35)25-32-19(39-2)12-20(33-25)40-3/h4-7,12H,8-11,13,30H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219275
(CHEMBL249691 | tert-butyl 4-(5-(aminomethyl)-2-(8-...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)33-11-9-32(10-12-33)22(34)20-17(13-29)37-21(31-20)15-5-7-16(36-4)19-14(15)6-8-18(30-19)25(26,27)28/h5-8H,9-13,29H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219284
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCCC3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C20H19F3N4O3/c1-29-13-6-4-12(11-5-7-15(20(21,22)23)25-16(11)13)18-26-17(14(10-24)30-18)19(28)27-8-2-3-9-27/h4-7H,2-3,8-10,24H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219276
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)c3ncccn3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C24H22F3N7O3/c1-36-16-5-3-15(14-4-6-18(24(25,26)27)31-19(14)16)21-32-20(17(13-28)37-21)22(35)33-9-11-34(12-10-33)23-29-7-2-8-30-23/h2-8H,9-13,28H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219274
(8-[5-aminomethyl-2-(8-methoxy-2-trifluoromethyl-qu...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCC4(CC3)N(CNC4=O)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C29H27F3N6O4/c1-41-20-9-7-19(18-8-10-22(29(30,31)32)35-23(18)20)25-36-24(21(15-33)42-25)26(39)37-13-11-28(12-14-37)27(40)34-16-38(28)17-5-3-2-4-6-17/h2-10H,11-16,33H2,1H3,(H,34,40) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50114418
(8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C17H10Cl2F3N3O2/c1-27-12-4-2-9(8-3-5-13(17(20,21)22)24-14(8)12)16(26)25-15-10(18)6-23-7-11(15)19/h2-7H,1H3,(H,23,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219271
(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)qu...)Show SMILES COc1ccc(-c2nc(C(N)=O)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H13F3N4O3/c1-25-9-4-2-8(15-23-13(14(21)24)10(6-20)26-15)7-3-5-11(16(17,18)19)22-12(7)9/h2-5H,6,20H2,1H3,(H2,21,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219290
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCC3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C19H17F3N4O3/c1-28-12-5-3-11(10-4-6-14(19(20,21)22)24-15(10)12)17-25-16(13(9-23)29-17)18(27)26-7-2-8-26/h3-6H,2,7-9,23H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219287
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCCCC3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C21H21F3N4O3/c1-30-14-7-5-13(12-6-8-16(21(22,23)24)26-17(12)14)19-27-18(15(11-25)31-19)20(29)28-9-3-2-4-10-28/h5-8H,2-4,9-11,25H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219293
(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)qu...)Show SMILES COc1ccc(-c2nc(C(O)=O)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H12F3N3O4/c1-25-9-4-2-8(14-22-13(15(23)24)10(6-20)26-14)7-3-5-11(16(17,18)19)21-12(7)9/h2-5H,6,20H2,1H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219270
(3,5-Dichloro-4-[(8-methoxy-2-trifluoromethyl-quino...)Show SMILES COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219286
(5-(aminomethyl)-N,N-diethyl-2-(8-methoxy-2-(triflu...)Show SMILES CCN(CC)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C20H21F3N4O3/c1-4-27(5-2)19(28)17-14(10-24)30-18(26-17)12-6-8-13(29-3)16-11(12)7-9-15(25-16)20(21,22)23/h6-9H,4-5,10,24H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219283
(4-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)qu...)Show SMILES COc1ccc(-c2nc(CN)c(o2)C(N)=O)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H13F3N4O3/c1-25-10-4-2-8(15-22-9(6-20)13(26-15)14(21)24)7-3-5-11(16(17,18)19)23-12(7)10/h2-5H,6,20H2,1H3,(H2,21,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219285
((2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)-5-...)Show SMILES COc1ccc(-c2nc(CN)c(C)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H14F3N3O2/c1-8-11(7-20)21-15(24-8)10-3-5-12(23-2)14-9(10)4-6-13(22-14)16(17,18)19/h3-6H,7,20H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219289
(2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)-5-m...)Show SMILES COc1ccc(-c2nc(C(N)=O)c(C)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H12F3N3O3/c1-7-12(14(20)23)22-15(25-7)9-3-5-10(24-2)13-8(9)4-6-11(21-13)16(17,18)19/h3-6H,1-2H3,(H2,20,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219294
(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)qu...)Show SMILES CNC(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C17H15F3N4O3/c1-22-15(25)14-11(7-21)27-16(24-14)9-3-5-10(26-2)13-8(9)4-6-12(23-13)17(18,19)20/h3-6H,7,21H2,1-2H3,(H,22,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219273
((Z)-(5-(aminomethyl)-2-(8-methoxy-2-(trifluorometh...)Show SMILES CO\N=C(\C1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F)c1ccccn1 Show InChI InChI=1S/C28H27F3N6O4/c1-39-20-8-6-18(17-7-9-22(28(29,30)31)34-24(17)20)26-35-25(21(15-32)41-26)27(38)37-13-10-16(11-14-37)23(36-40-2)19-5-3-4-12-33-19/h3-9,12,16H,10-11,13-15,32H2,1-2H3/b36-23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219268
(CHEMBL399298 | tert-butyl (R)-1-(5-(aminomethyl)-2...)Show SMILES COc1ccc(-c2nc(C(=O)N3CC[C@H](C3)NC(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)30-13-9-10-33(12-13)22(34)20-17(11-29)37-21(32-20)15-5-7-16(36-4)19-14(15)6-8-18(31-19)25(26,27)28/h5-8,13H,9-12,29H2,1-4H3,(H,30,35)/t13-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219274
(8-[5-aminomethyl-2-(8-methoxy-2-trifluoromethyl-qu...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCC4(CC3)N(CNC4=O)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C29H27F3N6O4/c1-41-20-9-7-19(18-8-10-22(29(30,31)32)35-23(18)20)25-36-24(21(15-33)42-25)26(39)37-13-11-28(12-14-37)27(40)34-16-38(28)17-5-3-2-4-6-17/h2-10H,11-16,33H2,1H3,(H,34,40) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219288
(2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)-5-m...)Show SMILES COc1ccc(-c2nc(C=O)c(C)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H11F3N2O3/c1-8-11(7-22)20-15(24-8)10-3-5-12(23-2)14-9(10)4-6-13(21-14)16(17,18)19/h3-7H,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219295
(8-methoxy-5-(4-methyloxazol-2-yl)-2-(trifluorometh...)Show InChI InChI=1S/C15H11F3N2O2/c1-8-7-22-14(19-8)10-3-5-11(21-2)13-9(10)4-6-12(20-13)15(16,17)18/h3-7H,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219282
(2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)-5-m...)Show SMILES COc1ccc(-c2nc(C(O)=O)c(C)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H11F3N2O4/c1-7-12(15(22)23)21-14(25-7)9-3-5-10(24-2)13-8(9)4-6-11(20-13)16(17,18)19/h3-6H,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219276
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)c3ncccn3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C24H22F3N7O3/c1-36-16-5-3-15(14-4-6-18(24(25,26)27)31-19(14)16)21-32-20(17(13-28)37-21)22(35)33-9-11-34(12-10-33)23-29-7-2-8-30-23/h2-8H,9-13,28H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219291
((2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)-5-...)Show SMILES COc1ccc(-c2nc(CO)c(C)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H13F3N2O3/c1-8-11(7-22)20-15(24-8)10-3-5-12(23-2)14-9(10)4-6-13(21-14)16(17,18)19/h3-6,22H,7H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219280
(5-(4-(chloromethyl)-5-methyloxazol-2-yl)-8-methoxy...)Show SMILES COc1ccc(-c2nc(CCl)c(C)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H12ClF3N2O2/c1-8-11(7-17)21-15(24-8)10-3-5-12(23-2)14-9(10)4-6-13(22-14)16(18,19)20/h3-6H,7H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219272
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCC(O)(CC3)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C27H25F3N4O4/c1-37-19-9-7-18(17-8-10-21(27(28,29)30)32-22(17)19)24-33-23(20(15-31)38-24)25(35)34-13-11-26(36,12-14-34)16-5-3-2-4-6-16/h2-10,36H,11-15,31H2,1H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219279
(2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)-5-(...)Show SMILES CNCc1oc(nc1C(N)=O)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C17H15F3N4O3/c1-22-7-11-14(15(21)25)24-16(27-11)9-3-5-10(26-2)13-8(9)4-6-12(23-13)17(18,19)20/h3-6,22H,7H2,1-2H3,(H2,21,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219272
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCC(O)(CC3)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C27H25F3N4O4/c1-37-19-9-7-18(17-8-10-21(27(28,29)30)32-22(17)19)24-33-23(20(15-31)38-24)25(35)34-13-11-26(36,12-14-34)16-5-3-2-4-6-16/h2-10,36H,11-15,31H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219275
(CHEMBL249691 | tert-butyl 4-(5-(aminomethyl)-2-(8-...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)33-11-9-32(10-12-33)22(34)20-17(13-29)37-21(31-20)15-5-7-16(36-4)19-14(15)6-8-18(30-19)25(26,27)28/h5-8H,9-13,29H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50219292
(5-(4-ethyloxazol-2-yl)-8-methoxy-2-(trifluoromethy...)Show InChI InChI=1S/C16H13F3N2O2/c1-3-9-8-23-15(20-9)11-4-6-12(22-2)14-10(11)5-7-13(21-14)16(17,18)19/h4-8H,3H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219269
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C26H26F3N7O5/c1-38-16-6-4-15(14-5-7-18(26(27,28)29)31-21(14)16)23-34-22(17(13-30)41-23)24(37)35-8-10-36(11-9-35)25-32-19(39-2)12-20(33-25)40-3/h4-7,12H,8-11,13,30H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219268
(CHEMBL399298 | tert-butyl (R)-1-(5-(aminomethyl)-2...)Show SMILES COc1ccc(-c2nc(C(=O)N3CC[C@H](C3)NC(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)30-13-9-10-33(12-13)22(34)20-17(11-29)37-21(32-20)15-5-7-16(36-4)19-14(15)6-8-18(31-19)25(26,27)28/h5-8,13H,9-12,29H2,1-4H3,(H,30,35)/t13-/m1/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219269
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C26H26F3N7O5/c1-38-16-6-4-15(14-5-7-18(26(27,28)29)31-21(14)16)23-34-22(17(13-30)41-23)24(37)35-8-10-36(11-9-35)25-32-19(39-2)12-20(33-25)40-3/h4-7,12H,8-11,13,30H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219278
(CHEMBL250137 | [5-aminomethyl-2-(8-methoxy-2-trifl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N7O4/c1-13-11-16(33-32-13)23(36)34-7-9-35(10-8-34)24(37)21-18(12-29)39-22(31-21)15-3-5-17(38-2)20-14(15)4-6-19(30-20)25(26,27)28/h3-6,11H,7-10,12,29H2,1-2H3,(H,32,33) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219275
(CHEMBL249691 | tert-butyl 4-(5-(aminomethyl)-2-(8-...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)33-11-9-32(10-12-33)22(34)20-17(13-29)37-21(31-20)15-5-7-16(36-4)19-14(15)6-8-18(30-19)25(26,27)28/h5-8H,9-13,29H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219278
(CHEMBL250137 | [5-aminomethyl-2-(8-methoxy-2-trifl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N7O4/c1-13-11-16(33-32-13)23(36)34-7-9-35(10-8-34)24(37)21-18(12-29)39-22(31-21)15-3-5-17(38-2)20-14(15)4-6-19(30-20)25(26,27)28/h3-6,11H,7-10,12,29H2,1-2H3,(H,32,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219273
((Z)-(5-(aminomethyl)-2-(8-methoxy-2-(trifluorometh...)Show SMILES CO\N=C(\C1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F)c1ccccn1 Show InChI InChI=1S/C28H27F3N6O4/c1-39-20-8-6-18(17-7-9-22(28(29,30)31)34-24(17)20)26-35-25(21(15-32)41-26)27(38)37-13-10-16(11-14-37)23(36-40-2)19-5-3-4-12-33-19/h3-9,12,16H,10-11,13-15,32H2,1-2H3/b36-23- | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219277
(4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)S(=O)(=O)N(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C22H25F3N6O5S/c1-29(2)37(33,34)31-10-8-30(9-11-31)21(32)19-16(12-26)36-20(28-19)14-4-6-15(35-3)18-13(14)5-7-17(27-18)22(23,24)25/h4-7H,8-12,26H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219281
(CHEMBL399385 | [5-aminomethyl-2-(8-methoxy-2-trifl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3ccccn3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C26H23F3N6O4/c1-38-18-7-5-16(15-6-8-20(26(27,28)29)32-21(15)18)23-33-22(19(14-30)39-23)25(37)35-12-10-34(11-13-35)24(36)17-4-2-3-9-31-17/h2-9H,10-14,30H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219276
((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)c3ncccn3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C24H22F3N7O3/c1-36-16-5-3-15(14-4-6-18(24(25,26)27)31-19(14)16)21-32-20(17(13-28)37-21)22(35)33-9-11-34(12-10-33)23-29-7-2-8-30-23/h2-8H,9-13,28H2,1H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219281
(CHEMBL399385 | [5-aminomethyl-2-(8-methoxy-2-trifl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3ccccn3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C26H23F3N6O4/c1-38-18-7-5-16(15-6-8-20(26(27,28)29)32-21(15)18)23-33-22(19(14-30)39-23)25(37)35-12-10-34(11-13-35)24(36)17-4-2-3-9-31-17/h2-9H,10-14,30H2,1H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219271
(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)qu...)Show SMILES COc1ccc(-c2nc(C(N)=O)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C16H13F3N4O3/c1-25-9-4-2-8(15-23-13(14(21)24)10(6-20)26-15)7-3-5-11(16(17,18)19)22-12(7)9/h2-5H,6,20H2,1H3,(H2,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219277
(4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)S(=O)(=O)N(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C22H25F3N6O5S/c1-29(2)37(33,34)31-10-8-30(9-11-31)21(32)19-16(12-26)36-20(28-19)14-4-6-15(35-3)18-13(14)5-7-17(27-18)22(23,24)25/h4-7H,8-12,26H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |