Reaction Details | |||
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Target | Glutamate receptor ionotropic, NMDA 2B | ||
Ligand | BDBM50220593 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_457343 (CHEMBL940934) | ||
Ki | >100±n/a nM | ||
Citation | Kawai, M; Sakurada, I; Morita, A; Iwamuro, Y; Ando, K; Omura, H; Sakakibara, S; Masuda, T; Koike, H; Honma, T; Hattori, K; Takashima, T; Mizuno, K; Mizutani, M; Kawamura, M Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation. Bioorg Med Chem Lett17:5537-42 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glutamate receptor ionotropic, NMDA 2B | |||
Name: | Glutamate receptor ionotropic, NMDA 2B | ||
Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
Type: | Protein | ||
Mol. Mass.: | 166077.66 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q00960 | ||
Residue: | 1482 | ||
Sequence: |
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BDBM50220593 | |||
n/a | |||
Name | BDBM50220593 | ||
Synonyms: | 6-hydroxy-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)methyl)pyridazine-3-carboxamide | CHEMBL399342 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H23N3O3 | ||
Mol. Mass. | 341.4042 | ||
SMILES | O=C(NC[C@H]1CC[C@@H](COc2ccccc2)CC1)c1ccc(=O)[nH]n1 |wU:4.3,7.7,(-3.93,-34.59,;-3.93,-36.13,;-2.59,-36.89,;-1.26,-36.12,;.08,-36.89,;1.41,-36.11,;2.74,-36.89,;2.74,-38.43,;4.07,-39.2,;5.4,-38.43,;6.74,-39.2,;6.73,-40.74,;8.06,-41.51,;9.4,-40.74,;9.39,-39.19,;8.06,-38.43,;1.41,-39.19,;.08,-38.43,;-5.26,-36.9,;-6.59,-36.13,;-7.92,-36.9,;-7.92,-38.44,;-9.25,-39.22,;-6.57,-39.21,;-5.25,-38.43,)| | ||
Structure |