Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50220598 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_457343 (CHEMBL940934) | ||
| Ki | 11±n/a nM | ||
| Citation |  Kawai, M; Sakurada, I; Morita, A; Iwamuro, Y; Ando, K; Omura, H; Sakakibara, S; Masuda, T; Koike, H; Honma, T; Hattori, K; Takashima, T; Mizuno, K; Mizutani, M; Kawamura, M Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation. Bioorg Med Chem Lett17:5537-42 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
| Type: | Protein | ||
| Mol. Mass.: | 166077.66 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q00960 | ||
| Residue: | 1482 | ||
| Sequence: |
| ||
| BDBM50220598 | |||
| n/a | |||
| Name | BDBM50220598 | ||
| Synonyms: | 6-oxo-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)methyl)-1,2,3,6-tetrahydropyridazine-3-carboxamide | CHEMBL251127 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H27N3O3 | ||
| Mol. Mass. | 357.4467 | ||
| SMILES | O=C(NC[C@@H]1CC[C@H](CCOc2ccccc2)CC1)C1NNC(=O)C=C1 |w:19.20,wU:4.3,7.7,c:26,(18.91,-43.44,;18.92,-44.98,;20.25,-45.74,;21.59,-44.97,;22.92,-45.73,;22.92,-47.27,;24.25,-48.04,;25.58,-47.27,;26.91,-48.05,;28.25,-47.28,;29.58,-48.05,;30.91,-47.28,;32.25,-48.06,;33.58,-47.29,;33.58,-45.75,;32.24,-44.98,;30.91,-45.75,;25.58,-45.73,;24.25,-44.96,;17.59,-45.75,;17.6,-47.29,;16.26,-48.06,;14.92,-47.29,;13.59,-48.05,;14.92,-45.75,;16.25,-44.98,)| | ||
| Structure | 
| ||