Reaction Details | |||
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Target | Glutamate receptor ionotropic, NMDA 2B | ||
Ligand | BDBM50220606 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_457343 (CHEMBL940934) | ||
Ki | 4.2±n/a nM | ||
Citation | Kawai, M; Sakurada, I; Morita, A; Iwamuro, Y; Ando, K; Omura, H; Sakakibara, S; Masuda, T; Koike, H; Honma, T; Hattori, K; Takashima, T; Mizuno, K; Mizutani, M; Kawamura, M Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation. Bioorg Med Chem Lett17:5537-42 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glutamate receptor ionotropic, NMDA 2B | |||
Name: | Glutamate receptor ionotropic, NMDA 2B | ||
Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
Type: | Protein | ||
Mol. Mass.: | 166077.66 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q00960 | ||
Residue: | 1482 | ||
Sequence: |
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BDBM50220606 | |||
n/a | |||
Name | BDBM50220606 | ||
Synonyms: | CHEMBL249093 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)methyl)-1H-pyrazole-4-carboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C19H25N3O2 | ||
Mol. Mass. | 327.4207 | ||
SMILES | O=C(NC[C@@H]1CC[C@H](CCOc2ccccc2)CC1)c1cn[nH]c1 |wU:4.3,7.7,(17.52,-15.71,;17.53,-17.25,;18.86,-18.01,;20.19,-17.24,;21.53,-18.01,;21.53,-19.55,;22.86,-20.31,;24.19,-19.55,;25.52,-20.32,;26.85,-19.55,;28.19,-20.32,;29.52,-19.55,;30.85,-20.33,;32.19,-19.56,;32.19,-18.02,;30.85,-17.25,;29.52,-18.02,;24.19,-18.01,;22.86,-17.23,;16.2,-18.02,;14.79,-17.4,;13.76,-18.55,;14.53,-19.88,;16.04,-19.55,)| | ||
Structure |