Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50411373 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_446344 (CHEMBL895464) | ||
IC50 | 125.89±n/a nM | ||
Citation | Micheli, F; Bonanomi, G; Blaney, FE; Braggio, S; Capelli, AM; Checchia, A; Curcuruto, O; Damiani, F; Fabio, RD; Donati, D; Gentile, G; Gribble, A; Hamprecht, D; Tedesco, G; Terreni, S; Tarsi, L; Lightfoot, A; Stemp, G; Macdonald, G; Smith, A; Pecoraro, M; Petrone, M; Perini, O; Piner, J; Rossi, T; Worby, A; Pilla, M; Valerio, E; Griffante, C; Mugnaini, M; Wood, M; Scott, C; Andreoli, M; Lacroix, L; Schwarz, A; Gozzi, A; Bifone, A; Ashby, CR; Hagan, JJ; Heidbreder, C 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists. J Med Chem50:5076-89 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50411373 | |||
n/a | |||
Name | BDBM50411373 | ||
Synonyms: | CHEMBL243860 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H37N5OS | ||
Mol. Mass. | 479.681 | ||
SMILES | CC1CCC(CC1)c1nnc(SCCCN2CCc3ccc(cc3CC2)-c2cc(C)on2)n1C |(16.41,-46.4,;15.16,-45.51,;13.75,-46.15,;12.5,-45.26,;12.65,-43.73,;14.04,-43.08,;15.3,-43.97,;11.39,-42.84,;11.37,-41.28,;9.91,-40.84,;9.02,-42.09,;7.48,-42.1,;6.7,-40.78,;5.16,-40.79,;4.38,-39.47,;2.84,-39.48,;2.16,-38.09,;.64,-37.76,;-.57,-38.74,;-1.9,-37.98,;-3.23,-38.75,;-3.23,-40.29,;-1.9,-41.06,;-.56,-40.29,;.67,-41.25,;2.18,-40.89,;-4.57,-41.06,;-5.96,-40.44,;-6.99,-41.58,;-8.51,-41.41,;-6.24,-42.93,;-4.73,-42.61,;9.94,-43.34,;9.48,-44.81,)| | ||
Structure |