| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM50227150 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461472 (CHEMBL927483) |
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| IC50 | 81±n/a nM |
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| Citation |  Hu, B; Quinet, E; Unwalla, R; Collini, M; Jetter, J; Dooley, R; Andraka, D; Nogle, L; Savio, D; Halpern, A; Goos-Nilsson, A; Wilhelmsson, A; Nambi, P; Wrobel, J Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity. Bioorg Med Chem Lett18:54-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM50227150 |
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| n/a |
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| Name | BDBM50227150 |
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| Synonyms: | 2-(4-((3-(3-benzoyl-8-(trifluoromethyl)quinolin-5-yl)phenoxy)methyl)phenyl)-3-(4-tert-butylphenyl)propanoic acid | CHEMBL253730 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H36F3NO4 |
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| Mol. Mass. | 687.7454 |
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| SMILES | CC(C)(C)c1ccc(CC(C(O)=O)c2ccc(COc3cccc(c3)-c3ccc(c4ncc(cc34)C(=O)c3ccccc3)C(F)(F)F)cc2)cc1 |w:9.8| |
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| Structure | 
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