Reaction Details |
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Target | Tryptophan 5-hydroxylase 1 |
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Ligand | BDBM50242929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_487488 (CHEMBL1016550) |
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IC50 | 31±n/a nM |
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Citation | Shi, ZC; Devasagayaraj, A; Gu, K; Jin, H; Marinelli, B; Samala, L; Scott, S; Stouch, T; Tunoori, A; Wang, Y; Zang, Y; Zhang, C; Kimball, SD; Main, AJ; Sun, W; Yang, Q; Nouraldeen, A; Yu, XQ; Buxton, E; Patel, S; Nguyen, N; Swaffield, J; Powell, DR; Wilson, A; Liu, Q Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem51:3684-7 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 1 |
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Name: | Tryptophan 5-hydroxylase 1 |
Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
Type: | PROTEIN |
Mol. Mass.: | 50990.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1361824 |
Residue: | 444 |
Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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BDBM50242929 |
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n/a |
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Name | BDBM50242929 |
Synonyms: | (S)-2-amino-3-(4-(5-((9-ethyl-9H-carbazol-3-yl)methylamino)pyrazin-2-yl)phenyl)propanoic acid | CHEMBL469463 |
Type | Small organic molecule |
Emp. Form. | C28H27N5O2 |
Mol. Mass. | 465.5463 |
SMILES | CCn1c2ccccc2c2cc(CNc3cnc(cn3)-c3ccc(C[C@H](N)C(O)=O)cc3)ccc12 |r| |
Structure |
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