| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Blk |
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| Ligand | BDBM4779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_540168 (CHEMBL1026516) |
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| IC50 | 29±n/a nM |
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| Citation |  Hur, W; Velentza, A; Kim, S; Flatauer, L; Jiang, X; Valente, D; Mason, DE; Suzuki, M; Larson, B; Zhang, J; Zagorska, A; Didonato, M; Nagle, A; Warmuth, M; Balk, SP; Peters, EC; Gray, NS Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase. Bioorg Med Chem Lett18:5916-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Blk |
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| Name: | Tyrosine-protein kinase Blk |
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| Synonyms: | B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk |
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| Type: | Protein |
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| Mol. Mass.: | 57711.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51451 |
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| Residue: | 505 |
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| Sequence: | MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
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| BDBM4779 |
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| n/a |
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| Name | BDBM4779 |
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| Synonyms: | CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib | N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide | PD0183805 | US10507209, Compound CI-1033 | US9730934, CI-1033 | cid_156414 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClFN5O3 |
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| Mol. Mass. | 485.938 |
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| SMILES | Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl |
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| Structure | 
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