Ki Summary

Reaction Details

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Target

Glucagon-like peptide 1 receptor

Ligand

BDBM50244458

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_513213 (CHEMBL977343)

IC50

4879±n/a nM

Citation

Kodra, JT; Jørgensen, AS; Andersen, B; Behrens, C; Brand, CL; Christensen, IT; Guldbrandt, M; Jeppesen, CB; Knudsen, LB; Madsen, P; Nishimura, E; Sams, C; Sidelmann, UG; Pedersen, RA; Lynn, FC; Lau, J Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem51:5387-96 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glucagon-like peptide 1 receptor

Name:

Glucagon-like peptide 1 receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

53035.78

Organism:

Homo sapiens (Human)

Description:

P43220

Residue:

463

Sequence:

MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

BDBM50244458

n/a

Name

BDBM50244458

Synonyms:

(S)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-tert-butylcyclohexyl)ureidomethyl]-benzoylamino}-2-hydroxypropionic acid | CHEMBL504156

Type

Small organic molecule

Emp. Form.

C30H35F6N3O5

Mol. Mass.

631.6064

SMILES

CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,wU:4.3,wD:22.24,7.10,(31.73,3.82,;31.73,2.27,;33.27,2.28,;30.19,2.27,;31.73,.73,;33.06,-.04,;33.06,-1.57,;31.72,-2.34,;30.39,-1.58,;30.39,-.04,;31.72,-3.88,;30.39,-4.65,;29.06,-3.88,;27.72,-4.66,;26.39,-3.89,;26.39,-2.34,;27.72,-1.57,;29.05,-2.33,;25.05,-1.57,;25.05,-.03,;23.72,-2.34,;22.39,-1.57,;21.05,-2.34,;21.05,-3.88,;19.72,-1.57,;19.72,-.03,;18.38,-2.34,;33.06,-4.65,;33.06,-6.19,;34.39,-3.88,;35.73,-4.64,;35.72,-6.19,;37.05,-6.95,;38.39,-6.18,;38.38,-4.63,;37.05,-3.87,;39.71,-3.86,;41.04,-3.07,;40.49,-5.18,;38.93,-2.53,;37.06,-8.49,;37.05,-10.03,;38.6,-8.5,;35.52,-8.5,)|

Structure