| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM50263554 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535681 (CHEMBL988835) |
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| IC50 | 440±n/a nM |
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| Citation |  Irie, O; Kosaka, T; Kishida, M; Sakaki, J; Masuya, K; Konishi, K; Yokokawa, F; Ehara, T; Iwasaki, A; Iwaki, Y; Hitomi, Y; Toyao, A; Gunji, H; Teno, N; Iwasaki, G; Hirao, H; Kanazawa, T; Tanabe, K; Hiestand, PC; Malcangio, M; Fox, AJ; Bevan, SJ; Yaqoob, M; Culshaw, AJ; Hart, TW; Hallett, A Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2. Bioorg Med Chem Lett18:5280-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50263554 |
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| n/a |
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| Name | BDBM50263554 |
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| Synonyms: | 2-cyano-N-methyl-4-(2-(1-methylpiperidin-4-yl)ethoxy)-6-(spiro[3.5]nonan-7-ylmethylamino)pyrimidine-5-carboxamide | CHEMBL478011 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H38N6O2 |
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| Mol. Mass. | 454.6082 |
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| SMILES | CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(nc1OCCC1CCN(C)CC1)C#N |
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| Structure | 
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