| Reaction Details |
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 | Report a problem with these data |
| Target | Motilin receptor |
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| Ligand | BDBM50254853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559937 (CHEMBL1013731) |
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| EC50 | 31.62±n/a nM |
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| Citation |  Westaway, SM; Brown, SL; Conway, E; Heightman, TD; Johnson, CN; Lapsley, K; Macdonald, GJ; MacPherson, DT; Mitchell, DJ; Myatt, JW; Seal, JT; Stanway, SJ; Stemp, G; Thompson, M; Celestini, P; Colombo, A; Consonni, A; Gagliardi, S; Riccaboni, M; Ronzoni, S; Briggs, MA; Matthews, KL; Stevens, AJ; Bolton, VJ; Boyfield, I; Jarvie, EM; Stratton, SC; Sanger, GJ The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. Bioorg Med Chem Lett18:6429-36 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Motilin receptor |
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| Name: | Motilin receptor |
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| Synonyms: | G-protein coupled receptor 38 | GPR38 | MLNR | MTLR | MTLR1 | MTLR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45365.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_122664 |
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| Residue: | 412 |
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| Sequence: | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
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| BDBM50254853 |
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| n/a |
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| Name | BDBM50254853 |
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| Synonyms: | CHEMBL464909 | N-[4'-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-biphenyl-2-ylmethyl]-2-(4-fluoro-phenoxy)-N-methyl-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34FN3O2 |
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| Mol. Mass. | 475.5976 |
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| SMILES | C[C@H]1CN(Cc2ccc(cc2)-c2ccccc2CN(C)C(=O)COc2ccc(F)cc2)C[C@@H](C)N1 |r| |
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| Structure | 
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