Reaction Details |
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Target | Endothelial lipase |
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Ligand | BDBM50254436 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_559992 (CHEMBL1018742) |
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IC50 | 300±n/a nM |
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Citation | Goodman, KB; Bury, MJ; Cheung, M; Cichy-Knight, MA; Dowdell, SE; Dunn, AK; Lee, D; Lieby, JA; Moore, ML; Scherzer, DA; Sha, D; Suarez, DP; Murphy, DJ; Harpel, MR; Manas, ES; McNulty, DE; Annan, RS; Matico, RE; Schwartz, BK; Trill, JJ; Sweitzer, TD; Wang, DY; Keller, PM; Krawiec, JA; Jaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett19:27-30 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelial lipase |
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Name: | Endothelial lipase |
Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
Type: | Protein |
Mol. Mass.: | 56805.62 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5X9 |
Residue: | 500 |
Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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BDBM50254436 |
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n/a |
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Name | BDBM50254436 |
Synonyms: | 5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid dimethylamide | CHEMBL468282 |
Type | Small organic molecule |
Emp. Form. | C14H17N3O4S |
Mol. Mass. | 323.367 |
SMILES | CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)c(C)o1 |
Structure |
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