| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50248472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_543009 (CHEMBL1018625) |
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| IC50 | 0.5±n/a nM |
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| Citation |  Sun, D; Wang, Z; Cardozo, M; Choi, R; Degraffenreid, M; Di, Y; He, X; Jaen, JC; Labelle, M; Liu, J; Ma, J; Miao, S; Sudom, A; Tang, L; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). Bioorg Med Chem Lett19:1522-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50248472 |
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| n/a |
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| Name | BDBM50248472 |
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| Synonyms: | 1,1,1-trifluoro-2-(4-((R)-2-methyl-4-((1-(pyridin-3-yl)cyclopropyl)methyl)piperazin-1-ylsulfonyl)phenyl)propan-2-ol | CHEMBL522463 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28F3N3O3S |
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| Mol. Mass. | 483.547 |
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| SMILES | C[C@@H]1CN(CC2(CC2)c2cccnc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F |r| |
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| Structure | 
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