| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50281226 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_196101 |
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| pH | 7±n/a |
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| IC50 | 0.350000±n/a nM |
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| Comments | extracted |
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| Citation |  Poss, MA; Reid, JA; Free, CA; Rogers, W; Weber, H; Ryono, DE; Dejneka, T; DeForrest, JM; Waldron, TL; Brittain, RJ; Weller, HN; Cimarusti, MP; Petrillo, EW Diol sulfonamides: A potent and novel class of inhibitors of human renin Bioorg Med Chem Lett3:2739-2744 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50281226 |
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| n/a |
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| Name | BDBM50281226 |
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| Synonyms: | CHEMBL328736 | N-[(S)-1-[(2R,3S)-4-((R)-Butylsulfamoyl)-1-cyclohexylmethyl-2,3-dihydroxy-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-(2-methyl-propane-2-sulfonylmethyl)-3-(S)-phenyl-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C35H57N5O8S2 |
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| Mol. Mass. | 739.986 |
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| SMILES | CCCCNS(=O)(=O)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)CS(=O)(=O)C(C)(C)C |
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| Structure | 
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