Reaction Details |
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Target | Renin |
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Ligand | BDBM50281242 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_196101 |
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pH | 7±n/a |
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IC50 | 240±n/a nM |
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Comments | extracted |
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Citation | Poss, MA; Reid, JA; Free, CA; Rogers, W; Weber, H; Ryono, DE; Dejneka, T; DeForrest, JM; Waldron, TL; Brittain, RJ; Weller, HN; Cimarusti, MP; Petrillo, EW Diol sulfonamides: A potent and novel class of inhibitors of human renin Bioorg Med Chem Lett3:2739-2744 (1993) Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50281242 |
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n/a |
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Name | BDBM50281242 |
Synonyms: | (S)-N-[(S)-4-((R,R)-Butylsulfamoyl)-1-cyclohexylmethyl-2,3-dihydroxy-butyl]-3-(3H-imidazol-4-yl)-2-(2-phenyl-ethanesulfonylamino)-propionamide | CHEMBL316558 |
Type | Small organic molecule |
Emp. Form. | C29H47N5O7S2 |
Mol. Mass. | 641.843 |
SMILES | CCCCNS(=O)(=O)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NS(=O)(=O)CCc1ccccc1 |
Structure |
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