Ki Summary

Reaction Details

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Target

Peroxisome proliferator-activated receptor alpha

Ligand

BDBM50293851

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_572400 (CHEMBL1036136)

EC50

0.550000±n/a nM

Citation

Liu, W; Liu, K; Wood, HB; McCann, ME; Doebber, TW; Chang, CH; Akiyama, TE; Einstein, M; Berger, JP; Meinke, PT Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia. J Med Chem52:4443-53 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Peroxisome proliferator-activated receptor alpha

Name:

Peroxisome proliferator-activated receptor alpha

Synonyms:

NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA | PPARA_CANLF

Type:

PROTEIN

Mol. Mass.:

52119.89

Organism:

Canis familiaris

Description:

ChEMBL_796444

Residue:

468

Sequence:

MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFSFTEYQYLGSG
PGSDGSVITDTLSPAPSPSSVTHPAAPGGAEEPSSVALNIECRICGDRASGYHYGVHACE
GCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEQDPEDAETADLKSLAKRIYEAYLKNFNMNKVKARVILAGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLKLHLQTNHPDNI
FLFPKLLQKMADLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

BDBM50293851

n/a

Name

BDBM50293851

Synonyms:

(2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}butanoic Acid | CHEMBL552240

Type

Small organic molecule

Emp. Form.

C28H23ClF3NO5

Mol. Mass.

545.934

SMILES

CC[C@@H](Oc1cccc(Cn2c(C)c(C(=O)c3ccc(Cl)cc3)c3ccc(OC(F)(F)F)cc23)c1)C(O)=O |r|

Structure