| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50297368 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_583250 (CHEMBL1055805) |
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| Ki | 1.58±n/a nM |
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| Citation |  Covel, JA; Santora, VJ; Smith, JM; Hayashi, R; Gallardo, C; Weinhouse, MI; Ibarra, JB; Schultz, JA; Park, DM; Estrada, SA; Hofilena, BJ; Pulley, MD; Smith, BM; Ren, A; Suarez, M; Frazer, J; Edwards, J; Hauser, EK; Lorea, J; Semple, G; Grottick, AJ Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity. J Med Chem52:5603-11 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50297368 |
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| n/a |
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| Name | BDBM50297368 |
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| Synonyms: | 4-{4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphenyl-4-sulfonyl}-morpholine | CHEMBL564380 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N2O3S |
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| Mol. Mass. | 414.561 |
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| SMILES | C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r| |
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| Structure | 
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