Reaction Details |
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Target | Histone-arginine methyltransferase CARM1 |
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Ligand | BDBM50301070 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_598368 (CHEMBL1037272) |
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IC50 | 17±n/a nM |
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Citation | Wan, H; Huynh, T; Pang, S; Geng, J; Vaccaro, W; Poss, MA; Trainor, GL; Lorenzi, MV; Gottardis, M; Jayaraman, L; Purandare, AV Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies. Bioorg Med Chem Lett19:5063-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone-arginine methyltransferase CARM1 |
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Name: | Histone-arginine methyltransferase CARM1 |
Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
Type: | Protein |
Mol. Mass.: | 65855.47 |
Organism: | Homo sapiens (Human) |
Description: | Q86X55 |
Residue: | 608 |
Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
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BDBM50301070 |
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n/a |
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Name | BDBM50301070 |
Synonyms: | 2-(2-methoxypyridin-3-yl)-4-methyl-6-(piperidin-4-yl)-1H-benzo[d]imidazole | CHEMBL577498 |
Type | Small organic molecule |
Emp. Form. | C19H22N4O |
Mol. Mass. | 322.4042 |
SMILES | COc1ncccc1-c1nc2c(C)cc(cc2[nH]1)C1CCNCC1 |
Structure |
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