Reaction Details |
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Target | Prostaglandin E synthase |
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Ligand | BDBM50302407 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_597591 (CHEMBL1050554) |
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IC50 | 450±n/a nM |
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Citation | Giroux, A; Boulet, L; Brideau, C; Chau, A; Claveau, D; Côté, B; Ethier, D; Frenette, R; Gagnon, M; Guay, J; Guiral, S; Mancini, J; Martins, E; Massé, F; Méthot, N; Riendeau, D; Rubin, J; Xu, D; Yu, H; Ducharme, Y; Friesen, RW Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett19:5837-41 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin E synthase |
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Name: | Prostaglandin E synthase |
Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
Type: | Protein |
Mol. Mass.: | 17112.22 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 152 |
Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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BDBM50302407 |
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n/a |
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Name | BDBM50302407 |
Synonyms: | 2-(6-bromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol | CHEMBL585763 |
Type | Small organic molecule |
Emp. Form. | C24H11BrClF7N2O |
Mol. Mass. | 591.703 |
SMILES | OC(c1ccc2c3[nH]c(nc3c3ccc(Br)cc3c2c1)-c1c(F)cccc1Cl)(C(F)(F)F)C(F)(F)F |
Structure |
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